A Literature Review of the Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates

Pediatric Cardiology
Liam MahoneyHeike Rabe

Abstract

Since its discovery in 1975 dobutamine has been used off-label for treating hemodynamic insufficiency in newborns and children. We present a structured literature review of pharmacokinetic and pharmacodynamic data for dobutamine in the pediatric population. Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria. Where possible, results for the pharmacodynamic and pharmacokinetic effect of dobutamine were reported as pooled data. Forty-six papers met the inclusion criteria. With regard to pharmacodynamic data a number of studies reported significant increases in a number of clinical parameters such as heart rate, blood pressure, cardiac output across a wide range of pediatric populations. With regard to pharmacokinetic data studies reported that the infusion rate was positively correlated to plasma dobutamine concentration. There was great variability with regard to dobutamine clearance between individuals and as to whether it followed first- or zero-order elimination kinetics. While the pharmacodynamic effects of dobutamine appear to reflect the pharmacological profile of the drug, the pharmacokinetic data are difficult to interpret due to inhomogeneity between study populat...Continue Reading

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Citations

Aug 5, 2016·Pediatric Research·Yvonne A EibyBarbara E Lingwood
Sep 3, 2016·Pharmaceutical Research·Nilay ThakkarDaniel Gonzalez
Nov 26, 2016·Pediatric Research·Victoria E MielgoCarmen Rey-Santano
Aug 19, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Heike Rabe, Hector Rojas-Anaya
Mar 15, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anna Cavigelli-BrunnerChristian Balmer
Feb 18, 2016·Annals of Intensive Care·Olivier BrissaudKhaldoun Kuteifan
Oct 29, 2019·British Journal of Clinical Pharmacology·Maarja HallikTuuli Metsvaht
Jun 16, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Wolfgang GöpelEgbert Herting
Jun 14, 2019·Frontiers in Pediatrics·María Carmen BravoAdelina Pellicer
Jan 23, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Heather M Siefkes, Satyan Lakshminrusimha
Nov 9, 2021·European Journal of Pediatrics·Yasser Elsayed, Muzafar Gani Abdul Wahab

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