A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

Frontiers in Oncology
Heleen KoningsKristien J Ledeganck

Abstract

Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of biomarkers, covering the different -omics fields to diagnose head and neck neoplasms in the early phase. To date, not a single biomarker, nor a panel of biomarkers for the detection of head and neck tumors has been detected with clinical applicability. Limitations for the clinical implementation of the investigated biomarkers are mainly the heterogeneity of the study groups (e.g., small population in which the biomarker was tested, and/or only including high-risk populations) and a low sensitivity and/or specificity of the biomarkers under study. Further research on biomarkers to diagnose head and neck neoplasms in an early stage, is therefore needed.

References

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Citations

Mar 6, 2021·International Journal of Computer Assisted Radiology and Surgery·Samireh BadrigilanMohsen Ebrahimi Moghaddam
Mar 18, 2021·International Journal of Oral Science·Bowen TanJinfeng Liao
Apr 4, 2021·International Journal of Molecular Sciences·Kumar RishabhAjaikumar B Kunnumakkara
Oct 15, 2021·Nutrition and Cancer·Tathiany Jéssica FerreiraMaria Aderuza Horst

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Methods Mentioned

BETA
biopsy
biopsies
glycosylation

Software Mentioned

MS
SIFT

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