PMID: 15332441Aug 31, 2004Paper

A locus for circadian period of locomotor activity on mouse proximal chromosome 3

Chronobiology International
Kari L KernekJohn R Hofstetter

Abstract

Lengthened circadian period of locomotor activity is a characteristic of a congenic strain of mice carrying a nonsense mutation in exon 5 of the carbonic anhydrase II gene, car2. The null mutation in car2 is located on a DBA/2J inbred strain insert on proximal chromosome 3, on an otherwise C57BL/6J genomic background. Since reducing the size of the congenic region would narrow the possible candidate genes for period, two recombinant congenic strains (R1 and R2) were developed from the original congenic strain. These new congenic strains were assessed for period, genetic composition, and the presence of immunoreactive carbonic anhydrase II. R1 mice were homozygous DBA/2J for the distal portion of the original DBA/2J insert, while R2 mice were homozygous DBA/2J for the proximal portion. R1 mice had a significantly lengthened period compared to R2 mice and wild-type C57BL/6J mice, indicating that the gene(s) affecting period is likely found within the reduced DBA/2J insert (approximately 1 cM) in the R1 mice. The R1 mice also possessed the null mutation in car2. This study confirmed the presence of a gene(s) affecting period on proximal chromosome 3 and significantly reduced the size of the congenic region and the number of candid...Continue Reading

References

Jun 1, 1993·Journal of Medical Genetics·S R ZeldenrustM D Benson
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T KondoC H Johnson
Nov 1, 1995·Behavior Genetics·J R HofstetterJ I Nurnberger
Oct 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T Roenneberg, J Rehman
Oct 4, 2000·Physiological Genomics·I Edery
May 8, 2004·Chronobiology International·Yvan TouitouLudger Rensing

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Citations

Oct 20, 2007·Genetics·Tae-Sung KimKwangwon Lee

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