A locus involved in kanamycin, chloramphenicol and L-serine resistance is located in the bglY-galU region of the Escherichia coli K12 chromosome

Molecular & General Genetics : MGG
P LejeuneA Danchin

Abstract

Spontaneous mutants of Escherichia coli K12 displaying an increased level of the kanamycin resistance conferred by plasmid pGR71 were selected. Several mutants obtained in this way apparently carry large chromosomal deletions extending into galU and/or bglY (27 min). This positive selection of deletions allowed detection of a new locus located between galU and bglY. Deletions of this locus are responsible for increased resistance to kanamycin (Irk), decreased resistance to L-serine in minimal medium (Drs) and decreased resistance to chloramphenicol (Drc) when a cat gene is present in the bacteria.

References

Apr 5, 1976·Biochemical and Biophysical Research Communications·M Uzan, A Danchin
Dec 1, 1986·Molecular & General Genetics : MGG·P R Cunningham, D P Clark
Apr 3, 1962·Biochemical and Biophysical Research Communications·T FUKASAWAK KURAHASHI
Dec 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·T A SUNDARARAJANH M KALCKAR

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Citations

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P Lejeune, A Danchin
Jul 21, 2005·Journal of Bacteriology·Sonia RodríguezAntonio Juárez
Oct 1, 2011·Current Opinion in Microbiology·Mostyn T BrownJudith P Armitage
Jul 1, 1993·Trends in Biochemical Sciences·R D'AriE B Newman
Sep 1, 1994·Journal of Bacteriology·P BertinE Collatz
Mar 1, 1991·Journal of Bacteriology·M R Leonardo, D P Clark
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·M K Berlyn

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