A long-lasting, single-dose nasal vaccine for Ebola: a practical armament for an outbreak with significant global impact

Expert Review of Anti-infective Therapy
Kristina Jonsson-Schmunk, Maria A Croyle

Abstract

In response to the severity and scale of the 2014 Ebola outbreak, several experimental vaccines were granted fast-track status for clinical testing. Although they may provide long-lasting protection from Ebola, they are, in their current states, far from optimal for populations that need them the most. In this context, nasal immunization addresses the: immune response required at the mucosa where Ebola initiates infection; needs of a population in terms of cost and compliance; and potency of each platform as they contain viruses that naturally infect the respiratory tract. Understanding the attributes of nasal immunization and its application will lead to potent vaccines that can effectively end Ebola and other emerging infectious diseases in developing and industrialized countries.

References

Nov 9, 1967·The New England Journal of Medicine·B N Fields, K Hawkins
Mar 25, 2009·Immunology and Cell Biology·Myron M Levine, Roy Robins-Browne
Apr 29, 2009·Expert Review of Vaccines·Dexiang Chen, Debra Kristensen
Oct 19, 2011·The Journal of Infectious Diseases·Stephan GüntherStefan Schmiedel
Apr 18, 2012·Vaccine·Myron M Levine
Sep 22, 2012·Veterinary Microbiology·Bettina ZimmerGert Zimmer
Jan 15, 2013·Drug Delivery and Translational Research·Per Gisle Djupesland
Jul 3, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jin Huk Choi, Maria A Croyle
Nov 8, 2013·Expert Review of Vaccines·Sonali KochharUNKNOWN Vienna Vaccine Safety Initiative
Nov 12, 2013·The Journal of Hospital Infection·C RotheS Thompson
Mar 1, 2014·Expert Review of Vaccines·Andrea Marzi, Heinz Feldmann
Jun 26, 2014·Expert Opinion on Drug Delivery·Peggy RieseCarlos A Guzmán
Jul 2, 2014·Clinical Microbiology Reviews·Thomas Lion
Aug 19, 2014·Annals of Internal Medicine·Carlos Del RioJeannette Guarner
Jan 1, 2015·EMBO Molecular Medicine·Almudena Marí SaézFabian H Leendertz

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