A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation

Proceedings of the National Academy of Sciences of the United States of America
Yukiteru NakayamaIchiro Manabe

Abstract

Proper resolution of inflammation is vital for repair and restoration of homeostasis after tissue damage, and its dysregulation underlies various noncommunicable diseases, such as cardiovascular and metabolic diseases. Macrophages play diverse roles throughout initial inflammation, its resolution, and tissue repair. Differential metabolic reprogramming is reportedly required for induction and support of the various macrophage activation states. Here we show that a long noncoding RNA (lncRNA), lncFAO, contributes to inflammation resolution and tissue repair in mice by promoting fatty acid oxidation (FAO) in macrophages. lncFAO is induced late after lipopolysaccharide (LPS) stimulation of cultured macrophages and in Ly6Chi monocyte-derived macrophages in damaged tissue during the resolution and reparative phases. We found that lncFAO directly interacts with the HADHB subunit of mitochondrial trifunctional protein and activates FAO. lncFAO deletion impairs resolution of inflammation related to endotoxic shock and delays resolution of inflammation and tissue repair in a skin wound. These results demonstrate that by tuning mitochondrial metabolism, lncFAO acts as a node of immunometabolic control in macrophages during the resolution...Continue Reading

References

Jan 1, 1975·Methods in Enzymology·B Middleton
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
Dec 22, 2010·Molecular Cell·Jing ZhaoJeannie T Lee
Aug 30, 2011·Nature·Mitchell GuttmanEric S Lander
Mar 1, 2012·Molecular & Cellular Proteomics : MCP·Zhenqi ZhouYuchun Du
Jun 5, 2012·Cell·Alfredo CastelloMatthias W Hentze
Aug 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo DengJames G Tidball
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Jan 29, 2013·Cell·Carla A KlattenhoffLaurie A Boyer
Jan 31, 2013·Nature Biotechnology·Woong Y HwangJ Keith Joung
Aug 3, 2013·Science·Susan CarpenterKatherine A Fitzgerald
Oct 5, 2013·The American Journal of Pathology·Margaret L Novak, Timothy J Koh
Dec 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhonghan LiTariq M Rana
Apr 2, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcin BulerJukka Hakkola
Apr 12, 2014·European Journal of Immunology·Huachun CuiGang Liu
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Feb 5, 2015·Nature Reviews. Molecular Cell Biology·Sven HeinzChristopher K Glass
Apr 7, 2015·Cell·Ci ChuHoward Y Chang
Jul 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennie ChanDaniel R Caffrey
Dec 19, 2015·Nature Immunology·Christopher K Glass, Gioacchino Natoli
Jan 16, 2016·Cell Systems·Arthur LiberzonPablo Tamayo

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Citations

Nov 4, 2020·RNA Biology·Katharina Walther, Leon N Schulte
Dec 5, 2020·Journal of Molecular and Cellular Cardiology·Seitaro Nomura, Issei Komuro
Apr 30, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qi LvYinan Zhang
May 15, 2021·Wiley Interdisciplinary Reviews. RNA·Nils Schmerer, Leon N Schulte
Jun 11, 2021·RNA Biology·Huixin LiangQiyi Zhao
Jun 27, 2021·International Immunology·Katsuhito Fujiu, Ichiro Manabe
Jan 23, 2022·Inflammation·Wangdong XuAnfang Huang

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