A Long-Term Control of Intramedullary Thoracic Spinal Cord Metastasis from Small Cell Lung Cancer

Acta Medica (Hradec Králové)
Hajime OsawaHiroaki Satoh

Abstract

Radiotherapy with systemic corticosteroid therapy has been used to treat intramedullary spinal cord metastasis (ISCM), but recovery of function and long-term survival of these patients has been rarely observed. We report herein a small cell lung cancer (SCLC) patient with recurrent thoracic ISCM, who was successfully treated with radiotherapy and systemic corticosteroid therapy. A 70-year-old man, who was diagnosed as having SCLC seven months previously, developed thoracic ISCM. Soon after the detection of the lesion, the patient received radiotherapy with systemic corticosteroid therapy. Sensory disturbance in both extremities and neurogenic bladder and bowel dysfunction was recovered. The patient could walk after irradiation again. The patient received additional chemotherapy and survived 20 months after the diagnosis of ISCM recurrence. Prompt diagnosis and appropriate treatment for ISCM and effective chemotherapy for recurrent SCLC might be the favorable factors for such patients. Further studies will be required to define a favorable subset of patients most likely to benefit from a conventional approach.

References

May 1, 1987·Archives of Neurology·M D WinkelmanN L Karlins
Feb 1, 1985·Journal of Neurosurgery·D A Costigan, M D Winkelman
Nov 22, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N FujimotoM Harada
Oct 11, 2005·Journal of Neuro-oncology·Melike MutMark E Shaffrey
Jul 26, 2006·European Journal of Internal Medicine·Georgios KoutsisNikolaos Zakopoulos
Feb 21, 2007·Journal of Neuro-oncology·Sung Sook LeeJin-Hee Ahn
Jun 21, 2007·CNS Drugs·Evert C A Kaal, Charles J Vecht
Sep 19, 2007·The Journal of Spinal Cord Medicine·Pamela E WilsonGerald H Clayton
Jul 16, 2011·Journal of Radiation Research·Haruko HashiiTetsuo Nishimura
Apr 26, 2014·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·S Katsenos, M Nikolopoulou
Jun 20, 2017·American Journal of Physical Medicine & Rehabilitation·Andrew Lamberth ParkerMark A Hirsch

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Coloproctology
Kyung Ho YangPyong Hwa Choi
Journal of Gastrointestinal Cancer
Vassilios VassiliouDimitrios Andreopoulos
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Y IshibashiH Isobe
© 2022 Meta ULC. All rights reserved