PMID: 8949430Sep 1, 1996Paper

A long-term multicentre assessment of the safety and tolerability of calcitriol ointment in the treatment of chronic plaque psoriasis

The British Journal of Dermatology
A LangnerH Verjans

Abstract

Calcitriol (1 alpha,25-dihydroxyvitamin D3), applied topically in an ointment base, has been shown to be effective in the treatment of chronic plaque psoriasis. This open study was designed to assess the safety and tolerability of 3 micrograms/g calcitriol ointment applied twice daily over treatment periods of up to 78 weeks. In the 253 evaluable patients with chronic plaque psoriasis no clinically relevant changes were observed in the baseline/end-point analyses of mean serum levels of total calcium, albumin-adjusted total calcium, phosphorus and creatinine, and plasma calcitriol levels. Mean values of 24-h urinary calcium, phosphorus, creatinine and hydroxyproline excretions, creatinine clearance and mean urinary calcium/creatinine ratio also did not show clinically relevant changes in the baseline/end-point analyses. The treatment was well tolerated, with no serious adverse events occurring during the course of the study. Eight patients withdrew from the study due to adverse events which, although not serious, were thought to be treatment-related: in seven patients skin irritation reactions and in one case a transient asymptomatic slight hypercalcaemia was observed. In addition, assessments of global severity, global improve...Continue Reading

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Citations

Oct 6, 1997·Clinics in Dermatology·K Fogh, K Kragballe
Jan 1, 2009·Clinical, Cosmetic and Investigational Dermatology·Lutz Kowalzick
Feb 14, 2015·The Journal of Dermatological Treatment·Marjolein I A Koetsier, Peter C M van de Kerkhof
Jul 5, 2005·Expert Opinion on Investigational Drugs·J J Guilhou
Jul 22, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Matthias AugustinKristian Reich
Apr 13, 2005·Acta Dermato-venereologica·Mark BerneburgFrauke Benedix
Mar 19, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andreas KörberUNKNOWN PsoNet Förderverein
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Anne R MasonHelen Hancock

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