A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review

International Journal of Surgery Case Reports
Masatsugu HirakiSeiji Sato

Abstract

Undifferentiated carcinoma of the liver is extremely rare. The biological characteristics and standard strategy for its treatment have not been established yet. A 45-year-old man was admitted because of fever elevation and shivering. Abdominal computed tomography revealed a hypovascular cystic mass in segments 6 and 7 of the liver measuring 11.5 × 9.0 cm with ring enhancement and partial solid component. A diagnosis of liver abscess was made, and percutaneous transhepatic abscess drainage was performed. Reddish brown-colored pus showed no bacteria or amoebas. However, cytology demonstrated malignant cells. After additional examinations of magnetic resonance imaging and the positron emission tomography, extended posterior sectionectomy with cholecystectomy was performed. The excised specimen showed a solid and irregular tumor with extensive central necrosis. A pathological examination revealed diffuse proliferation of oval- and spindle-shaped malignant cells. Immunohistochemically, the malignant cells were diffusely positive for AE1/AE3 and vimentin and focally positive for granulocyte colony-stimulating factor and cytokeratin 19; however, hepatocyte-specific antigen, glypican 3, cytokeratin 7, and CD56 were negative. Therefore,...Continue Reading

Citations

Jul 12, 2020·Clinical Journal of Gastroenterology·Nobuhiko OgasawaraHiromitsu Kumada
Dec 15, 2020·International Journal of Surgery Case Reports·Takanori OchiAkio Saiura
May 11, 2021·Case Reports in Hepatology·Brandon SwedGagandeep Brar

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surgical resection

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