PMID: 9163655May 1, 1997Paper

A longitudinal analysis of pulmonary function in rats during a 12 month cigarette smoke exposure

The European Respiratory Journal
J L WrightS Vedal

Abstract

We wanted to examine the longitudinal effects of chronic cigarette smoke exposure, and to determine whether the chronic alterations in pulmonary function induced by long-term cigarette smoke exposure in an animal model could be predicted by initial or early alterations in function. A group of Sprague Dawley rats was exposed to the smoke of 7 cigarettes x day(-1) for 5 days x week(-1) during a total period of 12 months. Lung volume, flow-volume curves and pressure-volume curves were recorded at baseline, and after 2, 4, 8 and 12 months of smoke exposure. A control group of rats was subjected to the same regimen of testing, but was not exposed to smoke. Thirteen rats completed the study in the smoke-exposed group and seven rats in the control group. We found that chronic exposure to cigarette smoke produced early abnormalities in pulmonary function, with the forced expiratory volume in one second/forced vital capacity (FEV1/FVC) ratio showing an acceleration of ageing effect, particularly between 4 and 8 months of exposure. In this model, although the two groups had significantly different airflow after 12 months, the initial values in each group were remarkably similar, and we could not identify any pulmonary function test which...Continue Reading

Citations

May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joanne L WrightAndrew Churg
Sep 28, 2005·Radiation and Environmental Biophysics·W F HeidenreichG Monchaux
May 17, 2012·Pediatric Pulmonology·Renee D GoodwinPeter M Lewinsohn
Dec 13, 2005·Pulmonary Pharmacology & Therapeutics·James G Martin, Meiyo Tamaoka
Dec 1, 2006·The Journal of Physiological Sciences : JPS·Sakurako TajiriHajime Yamabayashi
Jan 31, 2015·Journal of Applied Physiology·Bradford J SmithJason H T Bates
Sep 12, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Samanta Portão de CarlosGaspar Rogério da Silva Chiappa
May 16, 2002·Chest·Joanne L Wright, Andrew Churg

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