A longitudinal fMRI study of the paced auditory serial addition task

Multiple Sclerosis : Clinical and Laboratory Research
K S CardinalN L Sicotte


The paced auditory serial addition task (PASAT) is a test of working memory and attention that is frequently abnormal in MS and is used serially to assess cognitive dysfunction as part of the MS Functional Composite in clinical trials. Previous studies using functional MRI (fMRI) during PASAT performance have shown significant differences in activation patterns between healthy controls and MS patients matched for performance, but serial fMRI measures have not been reported. A confound is that learning effects are common with repeated PASAT testing, diminishing over successive trials. After measuring PASAT performance weekly for four weeks in 10 healthy controls to eliminate practice effects, we assessed brain activity using fMRI at baseline and after six months to determine the reproducibility of activation patterns in healthy controls during PASAT performance. Results showed that scores improved during the first three testing trials and stabilized subsequently. Brain activation during PASAT performance was seen in left frontal and parietal regions consistent with previous reports. After a six-month interval, PASAT performance and fMRI activity were stable, suggesting that serial fMRI during PASAT performance could be used as a...Continue Reading


Mar 5, 2011·The Cerebellum·Catherine J Stoodley
May 30, 2009·Disability and Rehabilitation·George J DemakisLloyd Dewald
Mar 29, 2011·Neurologic Clinics·Robert J FoxKen Sakaie
Jul 25, 2013·BJU International·Marylène JousseGérard Amarenco
Sep 13, 2011·NeuroImage·Catherine J StoodleyJeremy D Schmahmann
Oct 3, 2014·Applied Neuropsychology. Adult·Brian E Tapscott, Joseph Etherton
May 1, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Steven H P van de PavertOlga Ciccarelli
Jul 15, 2011·Arquivos de neuro-psiquiatria·Joseph Bruno Bidin BrooksYara Dadalti Fragoso
Dec 24, 2010·Multiple Sclerosis : Clinical and Laboratory Research·J Sastre-GarrigaA Rovira
Jul 19, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heather BrooksPACt-MD Study Group


Jan 1, 1990·Archives of Neurology·J M PeyserE Kaplan
Sep 14, 1974·Lancet·D Gronwall, P Wrightson
Jun 1, 1995·Current Opinion in Neurology·S M Rao
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Jun 4, 1999·Brain : a Journal of Neurology·G R CutterE Willoughby
Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
Sep 26, 2000·Microscopy Research and Technique·Hugh GaravanE A Stein
Jan 5, 2002·NeuroImage·K J WorsleyA C Evans
Dec 13, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·J RoyanM Francis
Jan 31, 2004·Journal of the International Neuropsychological Society : JINS·Alan H LockwoodDavid S Wack
Apr 2, 2004·The American Journal of Psychiatry·Albrecht HempelJohannes Schröder
Jun 19, 2004·Journal of Clinical and Experimental Neuropsychology·Tom N TombaughJ Kost
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Feb 16, 2005·Magma·Bertrand AudoinJ-P Ranjeva
May 20, 2005·Brain : a Journal of Neurology·Patrizia PantanoCarlo Pozzilli
Nov 18, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tom N Tombaugh
Jan 27, 2006·Cerebral Cortex·Adam Hampshire, Adrian M Owen
Apr 22, 2006·Journal of the Neurological Sciences·Caterina MaineroCarlo Pozzilli

Related Concepts

Immediate Recall
Memory for Designs Test
Longitudinal Survey
Cognition Disorders
Brain Activity
Claustral Structure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

© 2020 Meta ULC. All rights reserved