A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment

PloS One
Hiroi TomiokaMasaru Mimura

Abstract

Recent studies have indicated the potential clinical use of near infrared spectroscopy (NIRS) as a tool in assisting the diagnosis of major depressive disorder (MDD); however, it is still unclear whether NIRS signal changes during cognitive task are state- or trait-dependent, and whether NIRS could be a neural predictor of treatment response. Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the ...Continue Reading

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Citations

Apr 12, 2016·Frontiers in Psychology·Roberta AdorniAngelo Compare
Jun 28, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Je-Yeon YunJun Soo Kwon
Mar 30, 2017·NeuroImage. Clinical·Akihiro TakamiyaMasaru Mimura
Jan 31, 2019·Psychiatry Investigation·Yoshitaka NishizawaHiroshi Yoneda
Apr 5, 2020·International Journal of Molecular Sciences·Seung-Gul Kang, Seo-Eun Cho
Jun 27, 2019·Journal of Psychopharmacology·Darragh DowneyIan M Anderson
Apr 20, 2017·Fukushima Journal of Medical Science·Tsuyoshi HatakeyamaHirooki Yabe

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Methods Mentioned

BETA
MDD
pharmacotherapy
imaging techniques

Software Mentioned

VFT
MATLAB
SPSS

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