A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Parkinson Disease and Orthostatic Hypotension

Journal of Neuropathology and Experimental Neurology
Rossella InfanteV Donadio

Abstract

The aim of our study was to assess the distribution of phosphorylated α-synuclein (p-syn) deposits in a patient affected by early stage Parkinson disease and orthostatic hypotension through a longitudinal skin biopsy study. We found widespread p-syn spatial diffusion from deep autonomic dermis nerve bundles to autonomic terminals, suggesting a centrifugal spread of p-syn from ganglia to the innervation target structures. Furthermore, the case suggests the possibility of discriminating synucleinopathies at an early stage of disease by means of skin biopsy. If confirmed, these data support skin biopsy as a useful and promising tool for the diagnosis, longitudinal evaluation, and pathological understanding of Parkinson disease.

References

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May 3, 2014·Acta Neuropathologica·Kathrin DopplerClaudia Sommer
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Aug 24, 2018·Journal of Neuropathology and Experimental Neurology·Vincenzo DonadioRocco Liguori

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Citations

Nov 29, 2020·Parkinsonism & Related Disorders·Nicki NiemannJoseph Jankovic
Mar 26, 2021·Annals of Clinical and Translational Neurology·Todd D LevineRoy Freeman

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