A longitudinal study of antioxidant status during uncomplicated and hypertensive pregnancies

Acta Obstetricia Et Gynecologica Scandinavica
Eva Maria RoesEric Steegers

Abstract

To study the possible involvement of an (im)balance between oxidants and antioxidants in pre-eclampsia concentrations of intra- and extracellular blood antioxidants in women with uncomplicated and hypertensive pregnancies, they were studied preconceptionally and throughout pregnancy. In uncomplicated pregnancies (n = 19) and hypertensive pregnancies (n = 6) concentrations of whole blood and plasma thiols, plasma vitamins/E and C, hemoglobin, and hematocrit were assessed at preconception, 6, 10, 20, and 37 weeks of gestational age, as well as six weeks postpartum. A repeated mixed model was used for statistical analysis. Vitamin C and most whole blood and plasma thiol concentrations decreased during pregnancy, while vitamin E, whole blood oxidized cysteinyl-glycine and the ratio of free to oxidized homocysteine revealed a linear increase during pregnancy. Postpartum plasma cysteine and vitamin C levels and the ratio of free to oxidized levels of cysteine, cysteinyl-glycine, and glutathione were significantly (p <0.05) lower as compared to preconceptional levels, whereas whole blood oxidized cysteine, cysteinyl-glycine and glutathione levels, and whole blood and plasma homocysteine levels were significantly (p <0.05) higher six w...Continue Reading

Citations

Apr 4, 2013·Biomarkers in Medicine·Imran A SiddiquiWaleed Tamimi
May 4, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M A IkpenK C Ekwedigwe
Apr 23, 2009·Free Radical Research·Maria PalmSamar Basu
Oct 30, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seishi FurukawaHiroshi Sameshima
Sep 10, 2014·Frontiers in Physiology·Lesia O KurlakFiona Broughton Pipkin
May 30, 2015·Nutrition Reviews·Jose Guillermo Ortega ÁvilaAndrés Castillo
Jul 1, 2021·Journal of Ethnopharmacology·Lindiwe SibekoLorraine S Cordeiro
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology

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