A longitudinal study of computerized cognitive training in stroke patients - effects on cognitive function and white matter

Topics in Stroke Rehabilitation
Claudia Kim NybergKristine B Walhovd

Abstract

Background Computerized cognitive training is suggested to enhance attention and working memory functioning following stroke, but effects on brain and behavior are not sufficiently studied and longitudinal studies assessing brain and behavior relationships are scarce. Objective The study objectives were to investigate relations between neuropsychological performance post-stroke and white matter microstructure measures derived from diffusion tensor imaging (DTI), including changes after 6 weeks of working memory training. Methods In this experimental training study, 26 stroke patients underwent DTI and neuropsychological tests at 3 time points - before and after a passive phase of 6 weeks, and again after 6 weeks of working memory training (Cogmed QM). Fractional anisotropy (FA) was extracted from stroke-free brain areas to assess the white matter microstructure. Twenty-two participants completed the majority of training (≥18/25 sessions) and were entered into longitudinal analyses. Results Significant correlations between FA and baseline cognitive functions were observed (r = 0.58, p = 0.004), however, no evidence was found of generally improved cognitive functions following training or of changes in white matter microstructure...Continue Reading

References

Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·D W DesmondY Stern
May 2, 2002·Journal of the American Geriatrics Society·Mehool D PatelCharles D A Wolfe
Nov 6, 2002·Journal of the Neurological Sciences·Wendy ThamChristopher P L-H Chen
Jun 19, 2004·Stroke; a Journal of Cerebral Circulation·Hong Mei WenKa Sing Wong
Feb 4, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Torkel KlingbergHelena Westerberg
Oct 29, 2005·Stroke; a Journal of Cerebral Circulation·Teodoro del SerJose Vivancos
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Mar 17, 2007·Brain Injury : [BI]·H WesterbergT Klingberg
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Feb 16, 2010·Journal of Clinical and Experimental Neuropsychology·John WilliamsonPhilip Gorelick
Apr 22, 2010·Nature·Adrian M OwenClive G Ballard
Mar 29, 2011·Archives of Physical Medicine and Rehabilitation·Keith D CiceroneTeresa Ashman
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Dec 23, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Ramesh SahathevanGeoffrey A Donnan
May 23, 2012·Developmental Psychology·Monica Melby-Lervåg, Charles Hulme
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shir HofstetterYaniv Assaf
Sep 6, 2013·Nature·J A AngueraA Gazzaley
Jan 23, 2014·Lancet·Valery L FeiginUNKNOWN Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group
Oct 21, 2015·NeuroImage·Jesper L R Andersson, Stamatios N Sotiropoulos
Nov 3, 2016·The Journal of Head Trauma Rehabilitation·Yelena BogdanovaKeith D Cicerone
May 6, 2016·Frontiers in Human Neuroscience·Renate M van de VenBen A Schmand
Jul 31, 2016·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Monica Melby-LervågCharles Hulme
Oct 25, 2016·Neurobiology of Aging·Ann-Marie Glasø de LangeKristine B Walhovd
Sep 15, 2016·Stroke; a Journal of Cerebral Circulation·Pauline SchaapsmeerdersFrank-Erik de Leeuw

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.