A longitudinal study of epilepsy and other central nervous system diseases in individuals with and without a history of infantile autism

Brain & Development
Svend Erik MouridsenTorben Isager

Abstract

To compare the prevalence and types of epilepsy and other central nervous system (CNS) diseases in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with 336 matched controls from the general population. All participants were screened through the nationwide Danish National Hospital Register (DNHR). The average observation time was 30.3years (range 27-30years), and mean age at follow-up was 42.7years (range 27-57years). Of the 118 individuals with IA, 29 (24.6%) were registered with at least one epilepsy diagnosis against 5 (1.5%) in the comparison group (p<0.0001; OR=21.6; 95% CI 8.1-57.3). Other CNS diseases occurred with low frequency in both groups and only cerebral palsy, unspecified (p=0.02) was significantly more frequent among participants with a history of IA. Our study lends further support to the notion that epilepsy, but not other CNS diseases, is a common comorbid condition in IA. Low intelligence, but not gender, was a risk factor for epilepsy in IA.

References

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Citations

May 18, 2011·Journal of Autism and Developmental Disorders·Svend Erik MouridsenTorben Isager
Oct 12, 2012·Journal of Autism and Developmental Disorders·Svend Erik MouridsenTorben Isager
Mar 23, 2011·Current Neurology and Neuroscience Reports·Roberto Tuchman, Michael Cuccaro
Feb 5, 2011·Current Opinion in Neurology·Shafali S Jeste
May 8, 2014·Journal of Autism and Developmental Disorders·Elina JokirantaMatti Sillanpää
Mar 26, 2016·Frontiers in Chemistry·Gaurav Kaushik, Konstantinos S Zarbalis
Feb 13, 2013·Pharmacotherapy·Michele A Faulkner, Sanjay P Singh
Mar 3, 2012·Epilepsy & Behavior : E&B·Anne T Berg, Sigita Plioplys
Feb 19, 2013·Epilepsy & Behavior : E&B·Krista L Gilby, Terence J O'Brien
Sep 10, 2014·Nature Communications·Lori A OroscoKonstantinos S Zarbalis
Aug 6, 2013·American Journal of Physical Anthropology·Suzanna MihailidisGrant Townsend
Feb 6, 2014·Australian Dental Journal·G H Sperber, S M Sperber
Sep 11, 2020·Autism : the International Journal of Research and Practice·Pei-Yin PanUlf Jonsson
Jan 29, 2021·Journal of Personalized Medicine·Cristina PanisiVassilios Fanos
Jun 24, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·James T McCrackenUNKNOWN ISCTM/ECNP ASD Working Group

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