A Longitudinal Study of Local Gyrification Index in Young Boys With Autism Spectrum Disorder

Cerebral Cortex
Lauren E LiberoChristine Wu Nordahl

Abstract

Local gyrification index (LGI), a metric quantifying cortical folding, was evaluated in 105 boys with autism spectrum disorder (ASD) and 49 typically developing (TD) boys at 3 and 5 years-of-age. At 3 years-of-age, boys with ASD had reduced gyrification in the fusiform gyrus compared with TD boys. A longitudinal evaluation from 3 to 5 years revealed that while TD boys had stable/decreasing LGI, boys with ASD had increasing LGI in right inferior temporal gyrus, right inferior frontal gyrus, right inferior parietal lobule, and stable LGI in left lingual gyrus. LGI was also examined in a previously defined neurophenotype of boys with ASD and disproportionate megalencephaly. At 3 years-of-age, this subgroup exhibited increased LGI in right dorsomedial prefrontal cortex, cingulate cortex, and paracentral cortex, and left cingulate cortex and superior frontal gyrus relative to TD boys and increased LGI in right paracentral lobule and parahippocampal gyrus, and left precentral gyrus compared with boys with ASD and normal brain size. In summary, this study identified alterations in the pattern and development of LGI during early childhood in ASD. Distinct patterns of alterations in subgroups of boys with ASD suggests that multiple neur...Continue Reading

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Citations

Nov 25, 2019·Neuroimaging Clinics of North America·Jessica B Girault, Joseph Piven
Feb 6, 2021·Autism Research : Official Journal of the International Society for Autism Research·Hillary K Schiltz, Brooke E Magnus
May 8, 2021·Frontiers in Psychiatry·Mingmin NingJingyi Fan
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lin LiYiyong Chen
Jan 15, 2022·Brain Imaging and Behavior·Brendan TanNellie Georgiou-Karistianis

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