A longitudinal study of serial BODE indices in predicting mortality and readmissions for COPD

Respiratory Medicine
Fanny W S KoDavid S C Hui

Abstract

BODE index comprises Body mass index, Obstruction of the airway [FEV(1)], Dyspnoea score [modified Medical Research Council questionnaire] and Exercise capacity [6 min walk test]. This study assessed the role of serial changes in BODE index in predicting mortality and readmissions of COPD patients. A prospective cohort study involving 243(208 males) COPD patients hospitalized for acute exacerbations of COPD [AECOPD]. BODE index was assessed at 6 weeks(baseline), 6, 12, 18 and 24 months post hospital discharge. Mortality and readmissions in the subsequent 3 years were recorded. All the patients were managed by usual care without additional intervention. The mean (SD) age and FEV(1)% predicted were 74.2(7.8) yrs and 51.7(21.6)% respectively. Over the 3 years, 25.1% died whereas 76.5% had at least 1 readmission for AECOPD. Baseline BODE index was predictive of both the survival and readmissions to hospital for AECOPD by Cox regression analysis (p < 0.001 for both survival and readmissions). Over 24 months, 71(40.1%), 94(53.1%), 12(6.8%) patients had increased (>1 point), no change, and decreased in BODE (>1 point) index respectively. Serial changes in BODE index at 6 month was marginally associated with mortality, but not at 12-, ...Continue Reading

Associated Clinical Trials

References

Mar 1, 1988·Chest·D A Mahler, C K Wells
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
Jun 11, 1999·The European Respiratory Journal·G C DonaldsonJ A Wedzicha
Aug 23, 2005·Proceedings of the American Thoracic Society·Sanjay Sethi
Aug 23, 2005·Proceedings of the American Thoracic Society·Jadwiga A Wedzicha
Feb 16, 2006·Chest·Mary Sau-Man IpUNKNOWN Hong Kong Thoracic Society and American College of Chest Physicians (Hong Kong and Macau Chapter)
Mar 18, 2006·American Journal of Respiratory and Critical Care Medicine·Fernando J MartinezUNKNOWN NETT Research Group
Dec 26, 2006·Thorax·Stephen T Holgate
Jan 12, 2007·Journal of Occupational and Environmental Medicine·Theodore DarkowJenö P Marton
Jan 16, 2007·Chest·Dennis E NiewoehnerSteven Kesten
Jun 19, 2007·Chest·Fanny W S KoDavid S C Hui
Sep 4, 2007·Lancet·A Sonia BuistUNKNOWN BOLD Collaborative Research Group
Sep 20, 2007·Proceedings of the American Thoracic Society·David M Mannino, Sidney Braman
Jun 7, 2008·American Journal of Respiratory and Critical Care Medicine·Fernando J MartinezUNKNOWN National Emphysema Treatment Trial Research Group
Aug 9, 2008·Respiratory Medicine·Bartolome R CelliPaula M Meek
Aug 8, 2008·The European Respiratory Journal·F W S KoD S C Hui
Oct 31, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Moira Chan-YeungUNKNOWN Hong Kong Thoracic Society
Nov 18, 2008·Respiratory Medicine·Jose M MarinBartolome R Celli

❮ Previous
Next ❯

Citations

Jan 16, 2014·Annals of the American Thoracic Society·Valentin Prieto-CenturionJerry A Krishnan
Mar 5, 2016·Multidisciplinary Respiratory Medicine·Roberto W Dal Negro, Bartolome R Celli
Apr 26, 2016·Respiratory Medicine·Annika KarchUNKNOWN COSYCONET Study Group
Apr 6, 2013·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Antony M GrigonisAmanda M Dawson
Nov 2, 2016·International Journal of Palliative Nursing·Aoife GleesonRay Higginson
Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Beniamino GuerraMilo A Puhan
Jan 23, 2016·The European Respiratory Journal·Marc MiravitllesFrancesco Blasi
May 31, 2016·The Clinical Respiratory Journal·Hulya SahinAyse Ozsoz
Feb 15, 2020·ERJ Open Research·Spencer J KeeneRachel Jordan
Nov 17, 2020·Respiratory Medicine·Chidiamara M NjokuBonnie J Bereznicki
Aug 7, 2021·Respiratory Physiology & Neurobiology·Celal SaticiAyse Filiz Kosar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.