A longitudinal study of systemic inflammation and recovery of lean body mass among malnourished HIV-infected adults starting antiretroviral therapy in Tanzania and Zambia

European Journal of Clinical Nutrition
George PraygodJohn R Koethe

Abstract

The effects of inflammation on nutritional rehabilitation after starting antiretroviral therapy (ART) are not well understood. We assessed the relationship between inflammation and body composition among patients enrolled in the Nutritional Support for African Adults Starting Antiretroviral therapy (NUSTART) trial in Tanzania and Zambia from 2011 to 2013. HIV-infected, ART-eligible adults with body mass index (BMI) of <18.5 kg/m(2) enrolled in the NUSTART trial were eligible for this study. Anthropometric and body composition data were collected at recruitment and 6 and 12 weeks post ART and C-reactive protein (CRP) was measured at recruitment and 6 weeks. The relationships between CRP and body composition were assessed using multiple regression. Of the 1815 trial participants, 838 (46%) had baseline and 6-week CRP measurements. Median age was 36 years, 55% were females and median CD4 count was 135 cells/μl. A one-log reduction in CRP at 6 weeks was associated with increased mid-upper arm circumference (0.45 cm; 95% CI: 0.30, 0.61), calf circumference (0.38 cm; 0.23, 0.54), waist circumference (0.98 cm; 0.59, 1.37), BMI (0.37 kg/m(2); 0.24, 0.50) and fat-free mass (0.58 kg; 0.26, 0.91), but not with fat mass (0.09 kg; -0.17, 0....Continue Reading

Associated Clinical Trials

Apr 10, 2017·Dr George PrayGod

References

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Jan 30, 2015·BMC Medicine·UNKNOWN NUSTART (Nutritional Support for Africans Starting Antiretroviral Therapy) Study TeamPaul Kelly

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Citations

Feb 13, 2018·Current HIV/AIDS Reports·Mosepele Mosepele, Elizabeth Botsile
Oct 30, 2018·The Journal of Clinical Endocrinology and Metabolism·Juan TiraboschiDaniel Podzamczer
Feb 20, 2021·Current HIV/AIDS Reports·Hubaida FuseiniJohn R Koethe

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