Abstract
It has been demonstrated that regular fish consumption is associated with a reduced mortality from atherosclerotic cardiovascular disease (ASCVD). However, data are scarce regarding the correlation between the changes in the serum eicosapentaenoic acid/arachidonic acid (EPA/AA) ratio associated with regular fish consumption and the changes in the serum lipid profile variables. This study was designed as a hospital-based longitudinal study to investigate the relationship between the changes in the serum EPA/AA ratio and changes of the serum lipid levels in patients with one or more risk factors for ASCVD. In 475 patients followed-up for at least 1 year, univariable and multivariable regression analyses conducted after adjustments for the risk factors of ASCVD revealed that the absolute change of the EPA/AA ratio (∆EPA/AA ratio) was independently and significantly associated with the changes of the serum levels of low-density lipoprotein cholesterol (LDL-C) (β = - 0.129, p = 0.005), triglyceride (TG) (β = - 0.108, p = 0.019), non-high-density lipoprotein cholesterol (non-HDL-C) (β = - 0.149, p = 0.001), and TG/HDL-C ratio, a marker of the LDL particle size (β = - 0.104, p = 0.02), while not being correlated with any other lipid p...Continue Reading
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