A longitudinal study of the associations of BDNF genotype and methylation with poststroke anxiety

International Journal of Geriatric Psychiatry
Hee-Ju KangJae-Min Kim

Abstract

Although the precise etiology of poststroke anxiety (PSA) has yet to be fully elucidated, it is known that brain-derived neurotrophic factor (BDNF) is important for neural plasticity and long-term potentiation, associated with the pathophysiology of anxiety. The expression of BDNF is regulated by epigenetic and genetic profiles. Thus, we investigated the association between BDNF methylation status and PSA at 2 weeks and 1 year after stroke while accounting for interactions with the BDNF Val66Met polymorphism. The baseline sample comprised 286 patients who were assessed at 2 weeks after stroke; of these patients, 222 (78%) were followed up with at 1 year after stroke. The presence of PSA was determined using the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS), and the effects of BDNF methylation status and polymorphisms on PSA status were assessed with multivariate logistic regression models. The prevalence of PSA was slightly lower (27 [9.4%]) at baseline, and 35 (15.8%) patients were identified as having PSA at the 1-year follow-up. Stroke patients with a higher average methylation status were more likely to have PSA at 1 year. The BDNF Val66Met polymorphism was not independently associated with PSA during...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 1, 1997·Annual Review of Medicine·R G Robinson
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·S E KasnerA R Localio
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
May 18, 2004·European Journal of Pharmacology·Gabriel NowakAndrzej Pilc
Nov 3, 2004·Growth Factors·Devin K Binder, Helen E Scharfman
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
May 12, 2005·Behaviour Research and Therapy·Shmuel LissekDaniel S Pine
May 17, 2005·Brain Research. Molecular Brain Research·Félicien KaregeRomano La Harpe
Oct 15, 2005·Journal of Psychosomatic Research·Val MorrisonRon MacWalter
Feb 18, 2006·Nature Reviews. Drug Discovery·Christine B Yoo, Peter A Jones
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Osvaldo P Almeida, Jianguo Xiao
May 1, 2007·The Journal of Nervous and Mental Disease·Maeng Je ChoBong-Jin Hahm
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pedro BekinschteinJorge H Medina
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farah D LubinJ David Sweatt
Jun 16, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hilde BergersenAnne-Kristine Schanke
Sep 18, 2010·Journal of Psychosomatic Research·Cathy BrennanAllan House
Nov 19, 2010·International Journal of Geriatric Psychiatry·C DonnellanD O'Neill
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luye QinSunghee Cho
May 19, 2011·British Journal of Pharmacology·Amanda J SalesSâmia R L Joca
Feb 23, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Claudio D'AddarioA Carlo Altamura
Jul 28, 2012·Journal of Affective Disorders·Song ChiChen Zhang
Sep 28, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·C Alexia Campbell BurtonPeter Knapp
Feb 13, 2013·Journal of Affective Disorders·Jae-Min KimJin-Sang Yoon
Apr 17, 2013·Learning & Memory·Danay Baker-AndresenTimothy W Bredy
Dec 24, 2013·Brain and Cognition·Francesco AngelucciCarlo Caltagirone
Jan 2, 2014·Frontiers in Behavioral Neuroscience·Brigitte Schulz-KlausThomas Endres
Mar 25, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Natalie WederJoan Kaufman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.