PMID: 3752419May 1, 1986Paper

A longitudinal study of the influence of azathioprine on natural killer cell activity

Allergy
B K Pedersen, J M Beyer

Abstract

Natural killer (NK) cell activity against K562 target cells was studied in six patients with definite or classical rheumatoid arthritis before and during treatment with azathioprine. Azathioprine induced suppression of NK cell activity, but treatment with azathioprine for 5-8 months was necessary before NK cell activity was completely suppressed. In vitro incubation of mononuclear cells from a healthy donor with azathioprine or 6-mercaptopurine in concentrations not reducing cell viability did not inhibit NK cell activity, nor did sera from patients treated with azathioprine for more than 6 months.

References

May 1, 1985·Journal of Clinical Immunology·M BroganS Targan
Sep 1, 1972·Arthritis and Rheumatism·E SharonD Kaplan

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Citations

Jul 27, 2007·Diseases of the Colon and Rectum·Tilo StolzenburgHenrik Christensen
Oct 12, 1995·The New England Journal of Medicine·P J JohnsonR Williams
Sep 7, 2006·Journal of Pediatric Gastroenterology and Nutrition·Sanjoy BanerjeeWarren P Bishop
Mar 30, 2006·Transplantation·William H KitchensJoren C Madsen
Sep 1, 1991·Gut·P J Johnson, I G McFarlane
Feb 9, 2017·Clinical and Experimental Immunology·M S HasanF Fortune

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