A longitudinal study of the kidney function of the chimpanzee (Pan troglodytes) in comparison with humans

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
G Eder

Abstract

A prospective study of the kidney function of chimpanzees (Pan troglodytes) kept at the Hans Popper Primate Centre has been performed within the last 10 years. The aim of the study was to analyse urine samples for specific gravity, to determine serum creatinine, serum urea, and urinary creatinine, and to calculate creatinine clearance and reference values for healthy chimpanzees. From 1750 urine specimens of adolescent and 568 of infant chimpanzees a mean specific gravity value of 1.013 +/- 0.006 (standard deviation) kg/l and 1.007 +/- 0.003 (standard deviation) kg/l, respectively, was calculated. Serum creatinine was determined in 1864 single samples from 52 chimpanzees; a median value of 101.8 mumol/l (P (5%) 79.6 mumol/l, P (95%) 139.7 mumol/l) was calculated, which is higher than that in humans. Serum urea tests (n = 1831) in the same 52 chimpanzees resulted in a median value of 2.01 mmol/l (P (5%) 0.86 mmol/l, P (95%) 4.78 mmol/l). The calculated median creatinine clearance value of 23.9 ml/min (P (5%) 4.4 ml/min, P (95%) 65.3 ml/min) is lower in chimpanzees than in man. A correction of the creatinine clearance values to the body surface area of 1.73 m2, as routinely performed in humans, gave unusually high results, as the...Continue Reading

References

Jan 1, 1976·Birth Defects Original Article Series·F H Ruddle, P Meera Khan
Nov 1, 1990·Clinical Pharmacology and Therapeutics·D R LukeG R Matzke
May 1, 1990·AIDS·D L HeymannJ M Mann
Jun 1, 1988·Archives of Internal Medicine·T TakabatakeN Hattori
Oct 1, 1973·Annals of Internal Medicine·R W Jelliffe
Nov 1, 1967·American Journal of Clinical Pathology·K F BurnsS H Hampton
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·H BartelsC Heierli
Apr 1, 1981·Clinical Pharmacology and Therapeutics·J H HullA M Mattocks
Jul 1, 1957·The American Journal of Physiology·J A GAGNON, R W CLARKE
Mar 1, 1960·Journal of Clinical Pathology·J K FAWCETT, J E SCOTT
May 22, 1964·Deutsche medizinische Wochenschrift·J SCHIRMEISTERH KIEFER
Aug 28, 1964·Deutsche medizinische Wochenschrift·J SCHIRMEISTERW HALLAUER

❮ Previous
Next ❯

Citations

Aug 28, 2010·Sociological Inquiry·Richard York, Brett Clark
Mar 25, 2010·American Journal of Primatology·Siv Aina J LeendertzFabian H Leendertz
May 12, 2005·Health & Place·Sarah Wakefield, Colin McMullan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Primatology
Barbara A BeamanUlrich H Reichard
Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians
Janet M LanyonTrevor Long
Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians
Maureen FoxChet Thomas
© 2021 Meta ULC. All rights reserved