PMID: 2122625Sep 1, 1990Paper

A longitudinal study of total and free thyroid hormones and thyroxine binding globulin during normal puberty

Acta Endocrinologica
D B DungerR P Ekins

Abstract

Thyroid hormones are essential for normal pubertal growth, yet the changes in total and, especially, free thyroid hormones and thyroxine-binding globulin during puberty have not been adequately defined. Serum from 39 normal children (20 girls, 19 boys) between the ages of 10 and 15 years were assayed for total T4, free T4, free T3 and thyroxine-binding globulin at 6-monthly intervals; the free hormone assays were valid, non-analogue methodologies. In the girls, free T4 levels fell from 15.7 +/- 0.6 pmol/l at 10 years to 13.0 +/- 0.6 (p less than 0.001) at 12.5 years before rising to 15.9 +/- 0.7 at 15 years; this nadir occurred at puberty stages 3-4. Changes in total T4 followed a similar pattern with a slight delay in the nadir (13 years, puberty stage 4). In the boys, free T4 fell from 16.3 +/- 0.6 pmol/l at 10 years to 14.3 +/- 0.3 at 13.5 years, then rising to 15.4 +/- 0.5 at 15 years; the nadir again occurred at puberty stages 3-4. The corresponding nadir in total T4 which occurred at puberty stages 4-5 was not apparent by age analysis. Thyroxine-binding globulin concentrations remained unchanged in the girls, but fell slightly in the boys during later puberty. Free T3 concentrations in the girls showed a progressive fall ...Continue Reading

Citations

Nov 28, 2013·Journal of Human Evolution·Verena BehringerGottfried Hohmann
Mar 13, 2001·Journal of Molecular Biology·M P SebastiãoA M Damas
Mar 20, 1999·The Journal of Clinical Endocrinology and Metabolism·M L AhmedD B Dunger
Jun 7, 2019·Childhood Obesity·Aris GiannakopoulosChristina Kanaka-Gantenbein
Mar 18, 2011·Obstetrical & Gynecological Survey·Trimble L Bailey Spitzer
Jan 11, 2020·The Journal of Clinical Endocrinology and Metabolism·Purdey J CampbellJohn P Walsh
May 29, 1995·International Journal of Cancer. Journal International Du Cancer·M R GalantiA Ekbom
Dec 5, 2019·Frontiers in Neuroscience·Kassandra E CoupalVictoria E Claydon
Dec 17, 2011·Clinical Endocrinology·Raman Kumar MarwahaKalavani Mani
Mar 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·I G Jefferson

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