A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Henry Lik-Yuen ChanJoseph Jao-Yao Sung

Abstract

Serum hepatitis B surface antigen (HBsAg) quantification has been suggested to reflect the concentration of covalently closed circular DNA in the liver. We aimed to investigate the HBsAg levels at different stages of chronic hepatitis B and the changes in HBsAg level during the natural progression of disease. One hundred seventeen untreated patients with chronic hepatitis B were studied with longitudinal follow-up for 99 ± 16 months. HBsAg quantification was performed at the first visit, the last visit, and three visits at each quartile during the follow-up. At the first visit, HBsAg level was higher among patients who were hepatitis B e antigen (HBeAg)-positive (N = 49) than those who were HBeAg-negative (N = 68) (4.01 ± 0.91 log IU/mL versus 2.73 ± 1.25 log IU/mL, P < 0.001). HBsAg level was persistently high at approximately 5 log IU/mL among patients in the immune tolerance phase (N = 7). The HBsAg levels among patients with HBeAg-positive active disease (N = 25) or sustained HBeAg seroconversion (N = 17) were comparable at approximately 3-4 log IU/mL. The HBsAg levels among patients who were HBeAg-negative tended to be higher among patients with active (N = 46) than those with inactive disease (N = 22). The median HBsAg le...Continue Reading

References

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May 5, 2006·Seminars in Liver Disease·Henry Lik-Yuen Chan, Joseph Jao-Yiu Sung
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Jan 6, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Grace Lai-Hung WongHenry Lik-Yuen Chan
Apr 2, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maurizia Rossana BrunettoPatrick Marcellin
Jun 9, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent Wai-Sun WongHenry Lik-Yuen Chan
Oct 27, 2009·Drugs·Grace L-H Wong, Henry L-Y Chan
Oct 27, 2009·Journal of Hepatology·Henry Lik-Yuen Chan

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Citations

Jun 1, 2012·Hepatology International·Yun-Fan LiawMasao Omata
Aug 13, 2013·Clinics and Research in Hepatology and Gastroenterology·Stéphane Chevaliez
Jul 12, 2011·The Journal of Infectious Diseases·Roeland ZoutendijkHarry L A Janssen
Jul 12, 2011·The Journal of Infectious Diseases·Henry Lik-Yuen ChanVincent Wai-Sun Wong
Mar 23, 2011·Current Opinion in Gastroenterology·Hejun Yuan, William M Lee
Feb 23, 2012·Journal of Gastroenterology and Hepatology·Henry Lik-Yuen Chan
Sep 2, 2011·Clinical and Vaccine Immunology : CVI·B J ZacherF Bonino
Jan 1, 2014·World Journal of Gastroenterology : WJG·Il Han SongYoung Kwang Choo
Apr 26, 2014·World Journal of Gastroenterology : WJG·Yi-Min ZhangLan-Juan Li
May 31, 2014·World Journal of Gastroenterology : WJG·Li-Shuai Qu, Guo-Xiong Zhou
Sep 21, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Jeyamani RamachandranPriya Abraham
Mar 17, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mauro Viganò, Pietro Lampertico
May 30, 2014·Frontiers of Medicine·Jonathan Skupsky, Ke-Qin Hu
Apr 5, 2014·Gastroenterología y hepatología·Miriam RomeroJavier García-Samaniego
May 27, 2014·Journal of Clinical Gastroenterology·Lindsay A UribeMindie H Nguyen
Aug 6, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chia-Chi WangJia-Horng Kao
Nov 26, 2013·The Medical Clinics of North America·Brian J McMahon
Aug 3, 2013·Clinics in Liver Disease·Michelle Martinot-PeignouxPatrick Marcellin
Jan 7, 2016·Hepatology International·Hung-Chih Yang, Jia-Horng Kao
Dec 20, 2015·Gastroenterology·Jang-June ParkUNKNOWN HBRN
Nov 20, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R A A Pondé
Mar 28, 2012·Gastroenterology·Henry Lik-Yuen Chan
Dec 6, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian J McMahon, Brenna C Simons
Sep 7, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yi-Cheng ChenYun-Fan Liaw
Sep 7, 2011·Gastroenterology Clinics of North America·Maximilian Lee, Emmet B Keeffe
Sep 18, 2015·British Medical Bulletin·Carla S Coffin, Samuel S Lee
Dec 3, 2015·Journal of Clinical and Experimental Hepatology·Sundeep K GoyalManish Tripathi

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