A look at the brighter facets of β-N-oxalyl-l-α,β-diaminopropionic acid, homoarginine and the grass pea

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S L Rao

Abstract

The low incidence of neurolathyrism, its absence in several communities traditionally consuming Lathyrus sativus and the likely benefits of its inclusion as part of a normal diet are reviewed. The metabolism/detoxification of ODAP which is unique to humans may be a crucial factor in this regard. The presence of homoarginine in the pulse which has received scant attention in the past could make this an invaluable pulse since it could contribute to a sustained generation of NO. NO is well recognized for its role in cardiovascular physiology and general well-being and thus a daily dietary intake of homoarginine through small quantities of L. sativus may be of advantage and deserves to be exploited. The detoxification of ODAP in humans could spotlight the pulse further for its non-neurotoxic attributes. Activation of PKC by ODAP adds a new dimension to explore its possible therapeutic potentials in areas such as Alzheimer's disease, hypoxia, and long term potentiation. These novel approaches to both ODAP and homoarginine might entirely change our perception of this poor man's pulse.

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Citations

Apr 25, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S PilzW März
Mar 20, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S PilzA Fahrleitner-Pammer
Jun 19, 2012·Analytical and Bioanalytical Chemistry·Angela R Piergiovanni
Aug 4, 2012·PLoS Neglected Tropical Diseases·Delphin Diasolua NgudiFernand Lambein
Nov 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dirk Enneking
Nov 21, 2013·European Journal of Clinical Investigation·Stefan PilzJacqueline M Dekker
Mar 19, 2014·Thrombosis Research·Ling-Fang HuangZheng-Tao Wang
Dec 5, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Dorothee AtzlerChi-un Choe
Dec 23, 2016·Journal of Experimental Botany·Christopher Cullis, Karl J Kunert
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreia Bento-SilvaMaria do Rosário Bronze
Oct 3, 2020·Journal of the Science of Food and Agriculture·Rafaela SantosCatarina Prista
Jun 17, 2018·Toxicon : Official Journal of the International Society on Toxinology·Arjun L KhandareG S Toteja

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