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A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse

The Journal of Biological Chemistry

Feb 22, 2005

Takehito Tsuji, Tetsuo Kunieda

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Abstract

The achondroplastic mouse is a spontaneous mutant characterized by disproportionate dwarfism with short limbs and tail due to disturbed chondrogenesis during endochondral ossification. These abnormal phenotypes are controlled by an autosomal recessive gene (cn). In this study, linkage a...read more

Mentioned in this Paper

Natriuretic Peptide, C-Type
Transfection
Endochondral Ossification
Npr2 protein, rat
Extracellular
Protoplasm
COS-7 Cells
Chondrocyte
Chondrogenesis
Guanylate Cyclase Activity
30
1
Paper Details
References
  • References25
  • Citations56
123
  • References25
  • Citations56
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Chondrogenesis

Chondrogenesis is the earliest phase of skeletal development, involving mesenchymal cell recruitment and migration, condensation of progenitors, and chondrocyte differentiation, and maturation and resulting in the formation of cartilage and bone during endochondral ossification. Here is the latest research.

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A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse

The Journal of Biological Chemistry

Feb 22, 2005

Takehito Tsuji, Tetsuo Kunieda

PMID: 15722353

DOI: 10.1074/jbc.c500024200

Abstract

The achondroplastic mouse is a spontaneous mutant characterized by disproportionate dwarfism with short limbs and tail due to disturbed chondrogenesis during endochondral ossification. These abnormal phenotypes are controlled by an autosomal recessive gene (cn). In this study, linkage a...read more

Mentioned in this Paper

Natriuretic Peptide, C-Type
Transfection
Endochondral Ossification
Npr2 protein, rat
Extracellular
Protoplasm
COS-7 Cells
Chondrocyte
Chondrogenesis
Guanylate Cyclase Activity
30
1

Feeds With Similar Papers

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

sGC Modulators

Soluble guanylate cyclase (sGC) stimulators and activators have been developed to treat patients with pulmonary hypertension and heart failure, respectively. Recently these sGC modulators have been explored for the treatment of fibrosis. Discover the latest research on sGC modulators here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 2, 2004
Naohisa TamuraDavid L Garbers
Paper Details
References
  • References25
  • Citations56
123
  • References25
  • Citations56
12345...

Download from

Publisher
PubMed
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