PMID: 8461223Mar 1, 1993Paper

A loss of taurine and other amino acids from ventricles of patients undergoing bypass surgery

British Heart Journal
M S SuleimanR A Chapman

Abstract

To study the changes in amino acid content of left ventricles of patients during cardiac surgery that involves cardiopulmonary bypass and cold cardioplegia. Biopsy specimens (up to 10 mg wet weight) from the left ventricle of 30 patients undergoing coronary artery bypass graft and valve replacement surgery on cardiopulmonary bypass (protected by cold cardioplegia with St Thomas' solution) were taken immediately before the infusion of the cardioplegic solution and just before the removal of the cross clamp, and were analysed for their amino acid content. Of the most abundant cellular amino acids in the left ventricle taurine, glutamine, glutamate, and aspartate, but not alanine, showed a significant fall during the period of cross clamping. A rise in intracellular sodium (Na) is known to occur during cold cardioplegic arrest so that an activation of an amino acid/Na efflux, similar to that seen in animal experiments, seems a likely mechanism. The anomalous behaviour of alanine suggests some recovery of metabolism. The loss of alpha amino acids (by contrast with the loss of taurine) will depress protein synthesis and reduce energy reserves after cardiac surgery. Attempts to preserve the concentrations of intracellular alpha amino...Continue Reading

Associated Clinical Trials

Jun 21, 2007·Rolf SvedjeholmRolf Svedjeholm

References

Jun 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K A CongerF C Kauffman
Mar 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·M F Crass, J B Lombardini
Oct 1, 1977·Life Sciences·M F Crass, J B Lombardini
Nov 1, 1976·The Journal of Clinical Investigation·G H MudgeM Lesch
Sep 1, 1992·Cardiovascular Research·M S SuleimanR A Chapman
Jan 1, 1990·Annual Review of Physiology·M Tani
Mar 1, 1990·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·F DiederichsU Sommerfeld
Jun 1, 1990·International Journal of Cardiology·S K BhatnagarA R al Yusuf
Apr 1, 1989·International Journal of Cardiology·O I PisarenkoN A Pavlov
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·J E McMahonB R Kirkwood
Jul 1, 1988·Journal of Molecular and Cellular Cardiology·G J van der VusseR S Reneman
Apr 24, 1986·Nature·S A CohenT L Tarvin
Sep 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·J B Lombardini, D L Bricker
Jan 1, 1981·Advances in Experimental Medicine and Biology·M W Cooper, J B Lombardini
Sep 1, 1982·The American Journal of Physiology·J Y CheungJ V Bonventre

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Citations

Mar 1, 1997·The Annals of Thoracic Surgery·I BirdiA J Bryan
Apr 24, 2001·Pharmacology & Therapeutics·M S SuleimanE J Griffiths
Jul 31, 1998·Nutrition·H P RedmondD Bouchier-Hayes
Aug 10, 2006·Stress : the International Journal on the Biology of Stress·J M F Antunes-NetoD V Macedo
Jul 27, 2011·The Surgical Clinics of North America·Juan A SanchezStanley J Dudrick
Oct 27, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mårten VidlundRolf Svedjeholm
Jun 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P P StapletonD J Bouchier-Hayes
Apr 29, 2016·Oxidative Medicine and Cellular Longevity·Daniel Fudulu, Gianni Angelini
Aug 22, 2015·Journal of Nutrition and Metabolism·Marlieke VisserBas A J M de Mol
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H G PietersenA J Wagenmakers
Jan 23, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·P P StapletonD J Bouchier-Hayes
May 28, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·Mary Keith, Lee Errett

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