A Lotus japonicus Cochaperone Protein Interacts With the Ubiquitin-Like Domain Protein CIP73 and Plays a Negative Regulatory Role in Nodulation

Molecular Plant-microbe Interactions : MPMI
Heng KangZhongming Zhang

Abstract

The calcium/calmodulin-dependent protein kinase CCaMK forms a complex with its phosphorylation target CIP73 (CCaMK-interacting protein of 73 kDa). In this work, a homolog of the animal HSC/HSP70 interacting protein (HIP) was identified as an interacting partner of CIP73 in Lotus japonicus. L. japonicus HIP contains all functional domains characteristic of animal HIP proteins. The C-terminal STI1-like domain of L. japonicus HIP was found to be necessary and sufficient for interaction with CIP73. The interaction between CIP73 and HIP occurred in both the nuclei and cytoplasm in Nicotiana benthamiana leaf cells. The interactions between CIP73 and HIP and between CIP73 and CCaMK could take place simultaneously in the same nuclei. HIP transcripts were detected in all plant tissues tested. As nodule primordia developed into young nodules, the expression of HIP was down-regulated and the HIP transcript level became very low in mature nodules. More nodules were formed in transgenic hairy roots of L. japonicus expressing HIP RNA interference at 16 days postinoculation as compared with the control hairy roots expressing the empty vector. It appears that HIP may play a role as a negative regulator for nodulation.

References

Jan 1, 1994·Journal of Molecular Evolution·W R BoorsteinE A Craig
Apr 5, 1996·The Journal of Biological Chemistry·D TakezawaB W Poovaiah
Nov 1, 1996·Molecular and Cellular Biology·V PrapapanichD F Smith
Oct 1, 1996·Plant Molecular Biology·R S BostonE Vierling
Jan 24, 1997·The Journal of Biological Chemistry·H Irmer, J Höhfeld
Jan 31, 1998·Science·P De Koninck, H Schulman
Nov 11, 1999·Plant Physiology·J A Miernyk
Jan 11, 2000·Molecular and Cellular Biology·E A NollenR I Morimoto
Jan 13, 2000·Biochemistry·M VeltenM M Ladjimi
Jun 16, 2001·The Journal of Biological Chemistry·P V SathyanarayananB W Poovaiah
Oct 16, 2001·Cell Stress & Chaperones·M A WebbG A Thompson
Feb 13, 2004·The Journal of Biological Chemistry·Patricia E CarriganDavid F Smith
Sep 21, 2004·Annual Review of Plant Biology·Jeffrey F HarperAlice Harmon
Oct 23, 2004·Cell Stress & Chaperones·Amerigo CarrelloThomas Ratajczak
Aug 3, 2005·Nature Reviews. Molecular Cell Biology·Jeffrey F Harper, Alice Harmon
May 6, 2006·Molecular Plant-microbe Interactions : MPMI·Olivier GodfroyCharles Rosenberg
Oct 3, 2006·Apoptosis : an International Journal on Programmed Cell Death·Joseph A Caruso, John J Reiners
Feb 27, 2007·Journal of Zhejiang University. Science. B·Zheng-zheng ShiShu Zheng
Aug 29, 2007·Molecular Plant-microbe Interactions : MPMI·Elsa MessineseJean-Michel Ané
Jul 23, 2008·The Plant Journal : for Cell and Molecular Biology·Rainer WaadtJörg Kudla
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Koji YanoMartin Parniske
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benoit LefebvreThomas Ott
Jun 23, 2011·Molecular Plant-microbe Interactions : MPMI·Beatrix HorváthPéter Kaló
Jul 27, 2011·Molecular Plant-microbe Interactions : MPMI·Evgenia OvchinnikovaErik Limpens
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ward CapoenGiles E D Oldroyd
Oct 22, 2011·The Plant Journal : for Cell and Molecular Biology·Eigo FukaiMakoto Hayashi
Oct 22, 2011·The Plant Journal : for Cell and Molecular Biology·Dorian Fabian UrbańskiStig Uggerhøj Andersen

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Citations

Oct 9, 2018·Molecular Plant-microbe Interactions : MPMI·Liujian DuanZhongming Zhang

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