PMID: 8946021Nov 4, 1996Paper

A low, adaptive dose of gamma-rays reduced the number and altered the spectrum of S1- mutants in human-hamster hybrid AL cells

Mutation Research
A M UenoC A Waldren

Abstract

We examined the effects of a low, adaptive dose of 137Cs-gamma-irradiation (0.04 Gy) on the number and kinds of mutants induced in AL human-hamster hybrid cells by a later challenge dose of 4 Gy. The yield of S1- mutants was significantly less (by 53%) after exposure to both the adaptive and challenge doses compared to the challenge dose alone. The yield of hprt- mutants was similarly decreased. Incubation with cycloheximide (CX) or 3-aminobenzamide largely negated the decrease in mutant yield. The adaptive dose did not perturb the cell cycle, was not cytotoxic, and did not of itself increase the mutant yield above background. The adaptive dose did, however, alter the spectrum of S1- mutants from populations exposed only to the adaptive dose, as well as affecting the spectrum of S1- mutants generated by the challenge dose. The major change in both cases was a significant increase in the proportion of complex mutations compared to small mutations and simple deletions.

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C WaldrenT T Puck
May 19, 1977·Nature·L Samson, J Cairns
Feb 1, 1992·Mutation Research·J D Shadley, G Q Dai
Jan 1, 1990·Radiation and Environmental Biophysics·M Frankenberg-Schwager
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P N Rangarajan, G Padmanaban
Mar 1, 1989·Mutation Research·K SankaranarayananA T Natarajan
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C WaldrenT T Puck
Jul 1, 1987·Somatic Cell and Molecular Genetics·T T Puck, C A Waldren
Apr 1, 1987·Journal of Cellular Physiology·M S Sasaki, S Kodama
Dec 16, 1994·Science·L H Hartwell, M B Kastan

❮ Previous
Next ❯

Citations

Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Octávia Monteiro GilJosé Rueff
May 30, 1998·Biochemical Pharmacology·C Stecca, G B Gerber
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Markus LöbrichMichael Uder
Nov 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·David J BrennerMarco Zaider
Apr 25, 2008·Radiation Oncology·Silke B SchwarzMoshe Schaffer
Nov 24, 2012·The British Journal of Radiology·D J ShahD J Wilson
Sep 30, 2004·Radiation and Environmental Biophysics·Moshe SchafferEckhart Dühmke
Jun 10, 2008·Physics in Medicine and Biology·X George XuHarald Paganetti
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·C WaldrenA Ueno
Mar 1, 2005·Radiation Research·Ryuji OkazakiToshiyuki Norimura
Oct 9, 2007·Mutation Research·Fumio YatagaiFumio Hanaoka
Apr 30, 2009·International Journal of Radiation Biology·Lin LuYa Wang
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·R E J Mitchel
Jul 9, 2005·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Carley D RossMichael H Fox
Dec 21, 2007·Environmental and Molecular Mutagenesis·Michael KilemadeDouglas Boreham
Jan 5, 2002·Radiation Research·Rashi Iyer, Bruce E Lehnert
Aug 15, 2009·Journal of Radiation Research·Fumio YatagaiMasamitsu Honma
Feb 7, 2016·Journal of Radiation Research·Candy Y P NgKwan Ngok Yu
Jul 18, 2018·Dose-response : a Publication of International Hormesis Society·John J Cardarelli, Brant A Ulsh
Aug 11, 2018·Dose-response : a Publication of International Hormesis Society·Clément DevicNicolas Foray
Jan 5, 2011·Environmental Science & Technology·Guoping ZhaoLijun Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
T K HeiG Randers-Pehrson
Somatic Cell and Molecular Genetics
T T Puck, C A Waldren
Proceedings of the National Academy of Sciences of the United States of America
C A WaldrenT T Puck
Proceedings of the National Academy of Sciences of the United States of America
C WaldrenT T Puck
© 2021 Meta ULC. All rights reserved