A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice

The Journal of Steroid Biochemistry and Molecular Biology
H Bobby FokidisEmma S Tomlinson Guns

Abstract

Dietary factors continue to preside as dominant influences in prostate cancer prevalence and progression-free survival following primary treatment. We investigated the influence of a low carbohydrate diet, compared to a typical Western diet, on prostate cancer (PCa) tumor growth in vivo. LNCaP xenograft tumor growth was studied in both intact and castrated mice, representing a more advanced castration resistant PCa (CRPC). No differences in LNCaP tumor progression (total tumor volume) with diet was observed for intact mice (P = 0.471) however, castrated mice on the Low Carb diet saw a statistically significant reduction in tumor growth rate compared with Western diet fed mice (P = 0.017). No correlation with serum PSA was observed. Steroid profiles, alongside serum cholesterol and cholesteryl ester levels, were significantly altered by both diet and castration. Specifically, DHT concentration with the Low Carb diet was 58% that of the CRPC-bearing mice on the Western diet. Enzymes in the steroidogenesis pathway were directly impacted and tumors isolated from intact mice on the Low Carb diet had higher AKR1C3 protein levels and lower HSD17B2 protein levels than intact mice on the Western diet (ARK1C3: P = 0.074; HSD17B2: P = 0.0...Continue Reading

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Citations

Mar 21, 2019·Current Opinion in Oncology·Adeel KaiserChristopher D'Adamo
Mar 16, 2019·Carcinogenesis·Ingrid ElisiaGerald Krystal
Aug 21, 2019·Journal of the American Veterinary Medical Association·Alexandra RankovicAdronie Verbrugghe
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Mar 16, 2021·Frontiers in Nutrition·Ingrid Elisia, Gerald Krystal

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