A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study

Experimental Neurology
Sergio Gustavo EvrardAlicia Brusco

Abstract

Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking cessation of a chronic, but low, ethanol administration. Adolescent male Wistar rats were exposed to ethanol 6.6% (v/v) in drinking water for 6 weeks and studied after ending exposure or after a 10-week recovery period drinking water. Control animals received water. Brain sections were processed by immunohistochemistry using antibodies to serotonin (5-HT); glial fibrillary acidic protein (GFAP); astroglial S-100b protein; microtubule associated protein-2 (MAP-2); 200 kDa neurofilaments (Nf-200); and neuronal nitric oxide synthase (nNOS). The mesencephalic dorsal and median raphe nucleus (DRN; MRN) and three prosencephalic areas closely related to cognitive abilities (CA1 hippocampal area, striatum and frontal cortex) were studied by digital image analysis. 5-HT immunoreactivity (-ir) decreased in the DRN and recovered after abstinence and was not changed in the MRN. In the three prosencephalic areas, astrocytes' c...Continue Reading

References

Aug 1, 1991·Alcoholism, Clinical and Experimental Research·M J DruseN Tajuddin
Jan 1, 1990·Annals of the New York Academy of Sciences·J M Lauder
Apr 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BruscoJ Pecci Saavedra
Mar 1, 1995·Metabolic Brain Disease·G HallidayC Harper
May 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P M Whitaker-AzmitiaN Raio
Sep 17, 1993·Brain Research. Developmental Brain Research·E SundströmA Seiger
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H ReevesD C Hilt
Nov 1, 1993·Journal of Neuropathology and Experimental Neurology·G HallidayC Harper
Feb 1, 1996·Experimental Neurology·K OnizukaH Nishino
Jan 1, 1996·Behavioural Brain Research·P M Whitaker-AzmitiaJ M Lauder
Mar 17, 1997·Brain Research. Developmental Brain Research·A DinopoulosJ G Parnavelas
Apr 1, 1997·Molecular and Chemical Neuropathology·A BruscoR Duffard
Jun 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D A Lewis
Nov 5, 1997·Alcoholism, Clinical and Experimental Research·J A KimM J Druse
Dec 31, 1997·Journal of Neurochemistry·J HuL J Van Eldik
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
Jan 23, 1998·Molecular and Chemical Neuropathology·P TagliaferroA Brusco
May 15, 1998·Alcoholism, Clinical and Experimental Research·B J MarkwieseH S Swartzwelder
Jul 23, 1999·Brain Research·S T KaehlerA Philippu
May 24, 2000·British Journal of Pharmacology·G WegenerR Rosenberg
Oct 7, 2000·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·B AhluwaliaS Rajguru
Dec 5, 2000·Alcoholism, Clinical and Experimental Research·F T CrewsD J Knapp
Jan 5, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·M GerlachP Riederer
Feb 15, 2001·Journal of Biomedical Science·Y SariF C Zhou
Mar 15, 2001·Brain Research. Developmental Brain Research·F C ZhouT Li
Mar 16, 2001·Trends in Neurosciences·J P Kiss, E S Vizi
Mar 29, 2001·Brain Research Bulletin·P TagliaferroA Brusco
Apr 4, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·J SegiethP S Whitton

❮ Previous
Next ❯

Citations

Mar 13, 2010·Current Opinion in Psychiatry·Kimberly Nixon, Justin A McClain
Mar 19, 2011·Experimental Neurology·María Paula AronneAlicia Brusco
Jun 29, 2010·Journal of Affective Disorders·José Javier Miguel-HidalgoCraig A Stockmeier
Jul 7, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andreia Oliveira-da-SilvaYael Abreu-Villaça
Oct 19, 2011·Basic & Clinical Pharmacology & Toxicology·Joacim GötessonChris Pickering
Jan 26, 2013·Alcoholism, Clinical and Experimental Research·Dayna M HayesKimberly Nixon
Jun 18, 2010·CNS Neuroscience & Therapeutics·Trevor Archer
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Nympha B D'Souza El-GuindyGary G Meadows
Jan 3, 2014·Journal of Neurochemistry·Silvina TallisJuan C Perazzo
Apr 4, 2016·Alcoholism, Clinical and Experimental Research·Elisabetta GeraceDomenico E Pellegrini-Giampietro
May 21, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chelsea R GeilKimberly Nixon
May 3, 2014·Behavioural Brain Research·Giovana BroleseCarlos-Alberto Gonçalves
Sep 30, 2016·Pharmacological Reviews·Fulton T CrewsDonita L Robinson
Dec 6, 2016·Pharmacogenomics·Anna WardenR Dayne Mayfield
Dec 14, 2017·Frontiers in Behavioral Neuroscience·Eva M MarcoFernando Rodríguez de Fonseca
Apr 21, 2017·Frontiers in Cellular Neuroscience·Juan A OrellanaRodrigo A Quintanilla
Oct 11, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ronald KimKathryn J Reissner
Apr 11, 2008·Pediatrics·Ann S MastenLinda P Spear
Oct 10, 2020·Pharmacology, Biochemistry, and Behavior·Carly M Drzewiecki, Janice M Juraska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.