A low dose alcohol drug discrimination in social drinkers: relationship with subjective effects

Psychopharmacology
A JacksonT Duka

Abstract

Although well characterised in animals, relatively little is known about alcohol discriminative stimulus effects in humans. The study was carried out to investigate the correspondence of subjective effects and the discriminative response during the acquisition of a low dose alcohol discrimination in humans. Healthy volunteers completed an Alcohol Use Questionnaire and were then trained to discriminate a dose of 0.2 g/kg alcohol from placebo using a money reinforced technique. Subjects sampled drinks during training, but also completed rating scales measuring Taste, Like/Dislike and Subjective Effects for each drink. Thirty-two subjects learned the discrimination (discriminators; Ds). In these subjects, differences between placebo scores and alcohol scores for Lightheadedness, Relaxed, Arousal and Fatigue were greater following acquisition of the discrimination, compared with differences at the start of training. Differences in other measures remained consistent. Twenty-six of the volunteers failed to learn the discrimination (non-discriminators; NDs). These subjects reported drinking approximately twice as much alcohol during the preceding 6 months, as the Ds (4.35+/-0.53 g/kg per week versus 2.08+/-0.19 g/kg per week, respecti...Continue Reading

Citations

Jun 28, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Suzanne HiggsPhil Terry
Dec 27, 2005·Behavioural Pharmacology·Abigail K Rose, Theodora Duka
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Clyde W HodgeKeith L Shelton
Sep 27, 2014·Alcoholism, Clinical and Experimental Research·Dirk W LachenmeierJürgen Rehm
Apr 3, 2016·Psychopharmacology·Kenneth A PerkinsEric C Donny
Nov 8, 2005·Journal of Psychopharmacology·Anne JacksonTheodora Duka
Sep 30, 2003·Journal of Psychopharmacology·Anne JacksonDavid N Stephens
Aug 18, 2006·The Journal of Pharmacology and Experimental Therapeutics·Howard C Becker, Alicia M Baros
Apr 5, 2019·Pharmacology, Biochemistry, and Behavior·Mateo Leganes-FonteneauTheodora Duka

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