PMID: 9430521Jan 16, 1998Paper

A low-dose antimony treatment in 159 patients with American cutaneous leishmaniasis: extensive follow-up studies (up to 10 years)

The American Journal of Tropical Medicine and Hygiene
Manoel Paes Oliveira-NetoClaude Pirmez

Abstract

The efficacy of an antimony regimen at the dose of 20 mg/kg/day for a 3-4-week period is well established in the treatment of American cutaneous leishmaniasis. Several drug side effects, however, have been described and the search for more suitable regimens is advisable. In the present paper, the effect of a low dose (5 mg/kg/day for 30 days) of antimony was evaluated in 159 individuals from endemic regions of Rio de Janeiro State, Brazil, an area of Leishmania (V.) braziliensis transmission. Patients presented typical cutaneous lesions and parasites were demonstrated in all cases. One hundred forty-three patients were available for evaluation and of these, 120 (84%) were cured by the end of therapy. Twenty-three patients (16%) were considered treatment failures. Side effects were observed in only six patients (4%). Extensive follow-up (up to 10 years) disclosed no relapses or mucosal lesions. The results show that a low dose of antimony is less toxic, more appropriate, especially in children and elderly people, and has the same final result as that obtained with larger doses.

Citations

May 17, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·Armando de Oliveira SchubachMauro Célio de Almeida Marzochi
Nov 23, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Manoel Paes de Oliveira-Neto, Marise da Silva Mattos
Jul 8, 2008·Revista Do Instituto De Medicina Tropical De São Paulo·Alan César TeixeiraMario León Silva-Vergara
Dec 6, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Jamyra Iglesias CataldoMaria de Fátima Madeira
Nov 22, 2019·Science Translational Medicine·Camila Farias AmorimPhillip Scott
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SotoH Sindermann
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alejandro Llanos-CuentasFrancois Chappuis
May 17, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·Maria S AndradeSinval P Brandão-Filho
Apr 10, 2010·Expert Review of Anti-infective Therapy·Hiro Goto, José Angelo Lauletta Lindoso
Dec 4, 2009·Tropical Medicine & International Health : TM & IH·Diana Brito da Justa NevesRaimunda Nonato Ribeiro Sampaio
Nov 12, 2013·BMC Infectious Diseases·Augusto M CarvalhoEdgar M Carvalho
May 3, 2014·PLoS Neglected Tropical Diseases·Caspar J HodiamontTom van Gool
Mar 28, 2018·The American Journal of Tropical Medicine and Hygiene·Alexsandro Souza do LagoEdgar M Carvalho
May 16, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Alex Miranda RodriguesCor Jésus Fernandes Fontes
Jan 3, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·M P Oliveira-NetoG Grimaldi
Dec 8, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Sandra AndradeSinval Pinto Brandão-Filho
Jun 16, 2011·Photomedicine and Laser Surgery·Dennis SongMauricio S Baptista
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Denise S MatosSergio C F Mendonça
Mar 8, 2003·Revista Da Sociedade Brasileira De Medicina Tropical·Rilza Beatriz G de Azeredo-Coutinho, Sergio C F Mendonça
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SotoJ Berman
Nov 23, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Manoel Paes de Oliveira-Neto, Marise da Silva Mattos
Jan 14, 2009·Journal of Clinical Laboratory Analysis·Luiza C ReisValéria R A Pereira
Feb 9, 2011·The British Journal of Dermatology·K M P RodriguesC Pirmez
Sep 18, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Liliane de Fátima AntonioArmando de Oliveira Schubach
Jun 22, 2012·PLoS Neglected Tropical Diseases·Cristian ValenciaMirko Zimic
Dec 13, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naomi AronsonAlan Magill
Sep 30, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Marcelo Rosandiski LyraArmando Oliveria Schubach
Jan 25, 2005·Clinical and Experimental Dermatology·J E ZeegelaarW R Faber
Mar 27, 2002·Clinics in Geriatric Medicine·Mervyn L Elgart
May 19, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Davi Coe TorresJean-Claude Dujardin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.