A low-fat diet improves peripheral insulin sensitivity in patients with Type 1 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
A M RosenfalckJ Hilsted

Abstract

To compare the effects on insulin sensitivity, body composition and glycaemic control of the recommended standard weight-maintaining diabetes diet and an isocaloric low-fat diabetes diet during two, 3-month periods in patients with Type 1 diabetes. Thirteen Type 1 patients were included, of whom 10 completed the cross-over study. Ten non-diabetic, matched control subjects were also examined. Body composition was estimated by dual-energy X-ray absorptiometry (DXA) whole-body scanning, diet intake was monitored by 7-day dietary record and insulin sensitivity was measured by the insulin clamp technique at baseline and after each of the diet intervention periods. On an isocaloric low-fat diet, Type 1 diabetic patients significantly reduced the proportion of fat in the total daily energy intake by 12.1% (or -3.6% of total energy) as compared with a conventional diabetes diet (P = 0.039). The daily protein and carbohydrate intake increased (+4.4% of total energy intake, P = 0.0049 and +2.5%, P = 0.34, respectively), while alcohol intake decreased (-3.2% of total energy intake, P = 0.02). There was a significant improvement in insulin sensitivity on the isocaloric, low-fat diet compared with the standard diabetes diet [7.06 +/- 2.16 m...Continue Reading

References

Jun 1, 1992·The American Journal of Clinical Nutrition·J Lovejoy, M DiGirolamo
Jul 24, 1986·The New England Journal of Medicine·H Yki-Järvinen, V A Koivisto
Mar 11, 1971·The New England Journal of Medicine·J D BrunzellE L Bierman
Oct 1, 1983·Diabetes·H Yki-Järvinen, V A Koivisto
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·H Yki-Järvinen, V A Koivisto
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·H Yki-Järvinen, V A Koivisto
Sep 1, 1982·Metabolism: Clinical and Experimental·O PedersenN S Sørensen
May 1, 1980·Metabolism: Clinical and Experimental·H Beck-NielsenN S Sørensen
Sep 1, 1982·Diabetes Care·P HametP Larochelle
Dec 1, 1993·Diabetes·M G Carlson, P J Campbell
Jan 28, 1993·The New England Journal of Medicine·M BorkmanL V Campbell
Dec 1, 1995·The Journal of Clinical Investigation·D A PanL H Storlien
Apr 1, 1997·Journal of Applied Physiology·A GotfredsenJ Hilsted

❮ Previous
Next ❯

Citations

Jul 3, 2007·Internal Medicine·Ritsuko Yamamoto-HondaMitsuhiko Noda
Dec 25, 2008·The American Journal of Clinical Nutrition·Linda M DelahantyUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes
Feb 4, 2014·Canadian Journal of Diabetes·Catherine LerouxRémi Rabasa-Lhoret
Nov 28, 2013·Metabolism: Clinical and Experimental·Juan J ChillarónJuan Pedro-Botet
Oct 13, 2015·Metabolism: Clinical and Experimental·Kirti KaulMichael Roden
Feb 3, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·T T L Pang, P Narendran
Jul 24, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·A S BrazeauR Rabasa-Lhoret
Aug 22, 2015·Current Diabetes Reports·Rebecca Schechter, Sirimon Reutrakul
Apr 16, 2016·The American Journal of the Medical Sciences·Marion J Franz
Apr 29, 2010·Diabetes·Jonathan P GermanGregory J Morton
Apr 2, 2010·Diabetes Care·Esther DongaJohannes A Romijn
Apr 11, 2012·Nature Reviews. Endocrinology·Stephen J Cleland
Nov 1, 2012·Expert Review of Endocrinology & Metabolism·Marion J Franz
Dec 30, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Diana RubinThomas Skurk
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.