A low-fat, high-complex carbohydrate diet supplemented with long-chain (n-3) fatty acids alters the postprandial lipoprotein profile in patients with metabolic syndrome

The Journal of Nutrition
Yolanda Jiménez-GómezJosé López-Miranda

Abstract

Dietary fat intake plays a critical role in the development of metabolic syndrome (MetS). This study addressed the hypothesis that dietary fat quantity and quality may differentially modulate postprandial lipoprotein metabolism in MetS patients. A multi-center, parallel, randomized, controlled trial conducted within the LIPGENE study randomly assigned MetS patients to 1 of 4 diets: high-SFA [HSFA; 38% energy (E) from fat, 16% E as SFA], high-monounsaturated fatty acid [HMUFA; 38% E from fat, 20% E as MUFA], and 2 low-fat, high-complex carbohydrate [LFHCC; 28% E from fat] diets supplemented with 1.24 g/d of long-chain (LC) (n-3) PUFA (ratio 1.4 eicosapentaenoic acid:1 docosahexaenoic acid) or placebo (1.24 g/d of high-oleic sunflower-seed oil) for 12 wk each. A fat challenge with the same fat composition as the diets was conducted pre- and postintervention. Postprandial total cholesterol, triglycerides (TG), apolipoprotein (apo) B, apo B-48, apo A-I, LDL-cholesterol, HDL-cholesterol and cholesterol, TG, retinyl palmitate, and apo B in TG-rich lipoproteins (TRL; large and small) were determined pre- and postintervention. Postintervention, postprandial TG (P < 0.001) and large TRL-TG (P = 0.009) clearance began earlier and was fas...Continue Reading

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Citations

Aug 15, 2013·Reviews in Endocrine & Metabolic Disorders·Catherine J Andersen, Maria Luz Fernandez
Nov 17, 2011·The British Journal of Nutrition·Antonio CamargoJose Lopez-Miranda
May 19, 2012·Current Opinion in Lipidology·Jing PangGerald F Watts
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May 8, 2013·The Journal of Nutritional Biochemistry·Patricia Peña-OrihuelaJose Lopez-Miranda
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Jan 24, 2018·Critical Reviews in Food Science and Nutrition·Tyler Maher, Miriam E Clegg
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Sep 7, 2019·Nutrients·Stefania De SantisAntonio Moschetta
May 11, 2021·Frontiers in Endocrinology·Yunpeng GuanGuangyao Song

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