A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2

Lipids
Suélem Aparecida de FrançaNair Honda Kawashita

Abstract

The aim of this study was to evaluate thermogenesis in the interscapular brown adipose tissue (IBAT) of rats submitted to low-protein, high-carbohydrate (LPHC) diet and the involvement of adrenergic stimulation in this process. Male rats (~100 g) were submitted to LPHC (6%-protein; 74%-carbohydrate) or control (C; 17%-protein; 63%-carbohydrate) isocaloric diets for 15 days. The IBAT temperature was evaluated in the rats before and after the administration of noradrenaline (NA) (20 µg 100 g b w(-1) min(-1)). The expression levels of uncoupling protein 1 (UCP1) and other proteins involved in the regulation of UCP1 expression were determined by Western blot (Student's t test, P ≤ 0.05). The LPHC diet promoted a 1.1 °C increase in the basal temperature of IBAT when compared with the basal temperature in the IBAT of the C group. NA administration promoted a 0.3 °C increase in basal temperature in the IBAT of the C rats and a 0.5 °C increase in the IBAT of the LPHC group. The level of UCP1 increased 60% in the IBAT of LPHC-fed rats, and among the proteins involved in its expression, such as β3-AR and α1-AR, there was a 40% increase in the levels of p38-MAPK and a 30% decrease in CREB when compared to the C rats. The higher sympatheti...Continue Reading

References

Sep 6, 1979·Nature·N J Rothwell, M J Stock
Apr 1, 1986·Biochemical Society Transactions·B Cannon, J Nedergaard
Mar 1, 1985·The American Journal of Physiology·J Nedergaard, B Cannon
Feb 12, 1998·The Journal of Clinical Investigation·C A Siegrist-KaiserC A Meier
Feb 4, 1998·Obesity Research·N J Rothwell, M J Stock
Dec 4, 2003·Biochemical Society Transactions·C Holm
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Apr 10, 2004·The Journal of Biological Chemistry·Jong S RimLeslie P Kozak
Aug 18, 2004·The International Journal of Biochemistry & Cell Biology·Henrike SellDenis Richard
May 3, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jan NedergaardBarbara Cannon
Jul 10, 2007·Cell Metabolism·Patrick SealeBruce M Spiegelman
Oct 25, 2007·Cell·Stephane GestaC Ronald Kahn
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Jul 1, 2009·Diabetes·Patrick Seale, Mitchell A Lazar
Apr 15, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wouter D van Marken Lichtenbelt, Patrick Schrauwen
Aug 24, 2011·Annals of Nutrition & Metabolism·Mulchand S Patel, Malathi Srinivasan
Feb 7, 2012·The Journal of Clinical Investigation·Marica BordicchiaSheila Collins
Jan 10, 2014·Endocrine Journal·Masayuki Saito

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Citations

Feb 9, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine ChaumontetPatrick C Even
Sep 28, 2018·International Journal of Molecular Sciences·Christian CarpénéJosep Mercader
Jan 7, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Patrick C EvenDaniel Tomé
Mar 25, 2019·Physiology & Behavior·Daniel ToméDalila Azzout-Marniche
Oct 15, 2020·The Proceedings of the Nutrition Society·Daniel ToméDalila Azzout-Marniche
Jun 3, 2021·Nutrients·Karla J Suchacki, Roland H Stimson
Jun 1, 2021·Frontiers in Nutrition·Adel Pezeshki, Prasanth K Chelikani
Nov 16, 2019·Journal of Agricultural and Food Chemistry·Daniel ToméDalila Azzout-Marniche

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