A Low Psoas Muscle Index before Treatment Can Predict a Poorer Prognosis in Advanced Bladder Cancer Patients Who Receive Gemcitabine and Nedaplatin Therapy

BioMed Research International
Ryo KasaharaHiroji Uemura

Abstract

Introduction . Gemcitabine and cisplatin (GC) is a gold-standard first-line systemic chemotherapy for advanced urothelial carcinoma (UC). However, it may cause severe adverse effects such as renal toxicity, gastrointestinal toxicity, and neurotoxicity. Sarcopenia is the age-related loss of skeletal muscle mass. A correlation between sarcopenia and the oncological prognosis has been reported. In UC, several studies have noted that patients with sarcopenia had a greater incidence of complications and worse survival after radical cystectomy or chemotherapy. Our institute introduced gemcitabine and nedaplatin (GN) for UC patients with renal failure. We investigated whether the presence of sarcopenia predicted the prognosis of patients with advanced UC who were treated by GN chemotherapy.Methods. A total of 27 patients (male,n= 21; female,n= 6) received GN therapy for metastatic UC from 2005 to 2016. The institutional review board of Yokohama City University Hospital approved this study. The psoas muscle index (PMI, cm2/m2) was calculated using this formula: right psoas muscle area (cm2)/the square of the body height (m2). The overall survival (OS) of the high PMI group (male: ≥2.49, female: ≥2.07) and low PMI group (male: <2.49, fe...Continue Reading

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Citations

May 5, 2018·Annual Review of Nutrition·Elizabeth M Cespedes FelicianoBette J Caan
Oct 3, 2018·International Journal of Molecular Sciences·Hiroshi FukushimaFumitaka Koga
Oct 6, 2020·Oncotarget·Daiji TakkamotoHiroji Uemura
Nov 21, 2020·Scientific Reports·Julie A FitzpatrickBrandon Whitcher
Nov 13, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P J NavinN Takahashi
Oct 5, 2021·International Journal of Clinical Oncology·Ryutaro ShimizuAtsushi Takenaka
Oct 27, 2021·Current Opinion in Supportive and Palliative Care·Soum D LokeshwarMichael S Leapman

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