A lower dose of intravitreal conbercept effectively treats retinopathy of prematurity

Scientific Reports
Yong ChengJianhong Liang

Abstract

Intravitreal Conbercept (IVC) is the latest applied and effective treatment for the management of retinopathy of prematurity (ROP). However, conbercept escapes from the vitreous into the general circulation and reduce systemic VEGF concentrations. Thus, there are concerns about systemic complications, in these premature infants who are developing vital organ systems. This study is to determine whether a low dosage (0.15 mg/0.015 mL) of IVC is effective in the treatment of Zone II Stage 2/3 + ROP. A total of 38 eyes of 20 infants were analyzed retrospectively. We identified treatment effectiveness as complete regression of retinopathy and retinal vascularisation to zone III. The mean gestational age (GA), postmenstrual age (PMA) at treatment and birth weights (BW) were 28.6 ± 2.2 weeks, 39.3 ± 3.0 weeks and 1297.5 ± 429.2 g respectively. Primary effectiveness (react to IVC 0.15 mg alone) was found in 32/38 eyes (84.2%). Secondary effectiveness (a second IVC was required) was found in 6/38 eyes (15.8%). Follow-up continued until 90 weeks' postmenstrual age and showed no recurrences of plus disease or neovascularization. The study suggests 0.15 mg IVC is effective for Zone II Stage 2/3 + ROP, and there is no adverse ocular outcome...Continue Reading

References

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Jul 13, 2005·Archives of Ophthalmology·UNKNOWN International Committee for the Classification of Retinopathy of Prematurity
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Feb 18, 2011·The New England Journal of Medicine·Helen A Mintz-HittnerUNKNOWN BEAT-ROP Cooperative Group
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Oct 31, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Alireza KhodabandeRamak Roohipoor
Apr 28, 2017·JAMA Ophthalmology·David K WallaceUNKNOWN Pediatric Eye Disease Investigator Group (PEDIG)
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Oct 8, 2017·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Anna L EllsAlexander S Platt

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Citations

Nov 20, 2020·Journal of Pediatric Ophthalmology and Strabismus·Christopher W SeeryRudolph S Wagner
Jul 23, 2020·Asia-Pacific Journal of Ophthalmology·Ana Bety EnríquezCaroline R Baumal
Jan 19, 2022·European Journal of Ophthalmology·Alfredo BeccasioCarlo Cagini

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