A lower level of reduced albumin induces serious cardiovascular incidence among peritoneal dialysis patients.

Clinical and Experimental Nephrology
Hiroyuki TerawakiTatsuo Hosoya

Abstract

Human serum albumin is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers and of oxidized human non-mercaptoalbumin. Previously, we reported that a lower HMA level is closely related to serious cardiovascular disease (CVD) incidence and mortality among hemodialysis patients. However, the relationship between HMA level and CVD incidence among peritoneal dialysis (PD) patients is unclear. We measured the redox state of human serum albumin using high-performance liquid chromatography in 30 continuous ambulatory PD patients. The association between HMA and incidental CVD events was evaluated. Eight patients experienced symptomatic CVD events (5 patients died) at the 5-year follow-up. The concentration and fraction of HMA (cHMA and f(HMA), respectively) showed significantly lower values in patients with CVD than those without CVD (cHMA 1.58 ± 0.39 and 2.16 ± 0.43 g/dL, f(HMA) 48.9 ± 5.4 and 56.4 ± 8.6%, respectively). Multiple forward stepwise regression analysis using cHMA and f(HMA) as the criterion variables was performed, and C-reactive protein and hemoglobin were adopted as significant explanatory variables in the former equation, whereas urea nitrogen was adopted in the latter equation. Multi...Continue Reading

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Citations

Dec 10, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lucía TurellRafael Radi
Jul 24, 2012·Clinical and Experimental Nephrology·Hiroyuki TerawakiTatsuo Hosoya
Nov 30, 2012·Clinical and Experimental Nephrology·Hiroyuki TerawakiSadayoshi Ito
Nov 28, 2013·Hemodialysis International·Hiroyuki TerawakiMasaaki Nakayama
Apr 18, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kojiro NagaiJun Minakuchi
Jun 12, 2013·Free Radical Biology & Medicine·Lucía TurellBeatriz Alvarez
Nov 15, 2018·American Journal of Physiology. Renal Physiology·Ryosuke FujiiTakaaki Kondo
Dec 20, 2019·Geriatrics & Gerontology International·Hironobu AshikawaSumio Yamada
Apr 4, 2021·Antioxidants·Stefanny M FigueroaCristián A Amador

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Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Hiroyuki TerawakiTatsuo Hosoya
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Hiroyuki TerawakiTatsuo Hosoya
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