A lubricious formulation exhibiting reduced thrombogenicity, cell proliferation, and protein adsorption

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Pasquale P VicarioTom Schottman

Abstract

The adhesion of human platelets, erythrocytes, and leukocytes, the adsorption of protein, and the proliferation of human umbilical vein endothelial cells (HUVEC) on the surface of electropolished stainless steel and the lumen of polyurethane tubing coated with Hydromer's lubricious Duality T8B formulation was evaluated. Following exposure to a platelet-enriched suspension from citrated human whole blood, stainless steel coated with this formulation exhibited significantly reduced adhesion of platelets, erythrocytes, and granulocytes. This reduction in adhesion was confirmed using an immunohistochemical method utilizing antibodies to CD41, CD235, and CD15, respectively. The proliferation of HUVEC cells were significantly reduced when cultured on coated stainless steel. This formulation was also able to significantly reduce the adsorption of plasma proteins and the major protein in tear fluid (lysozyme) to the surface of stainless steel. The nonthrombogenic properties of Duality T8B after application to the lumen of polyurethane tubing were also examined. Following a short-term (3 h) static exposure to citrated human whole blood, microscopic examination revealed that the adhesion of platelets and erythrocytes was reduced signific...Continue Reading

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Citations

Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Maria StioFrancesca Borgioli
Dec 24, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Iseult LynchMichaela Kendall

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