A lumpy skin disease virus deficient of an IL-10 gene homologue provides protective immunity against virulent capripoxvirus challenge in sheep and goats

Antiviral Research
Hani BoshraShawn Babiuk

Abstract

Sheep and goat pox continue to be important livestock diseases that pose a major threat to the livestock industry in many regions in Africa and Asia. Currently, several live attenuated vaccines are available and used in endemic countries to control these diseases. One of these is a partially attenuated strain of lumpy skin disease virus (LSDV), KS-1, which provides cross-protection against both sheep pox and goat pox. However, when used in highly stressed dairy cattle to protect against lumpy skin disease (LSD) the vaccine can cause clinical disease. In order to develop safer vaccines effective against all three diseases, a pathogenic strain of LSDV (Warmbaths [WB], South Africa) was attenuated by removing a putative virulence factor gene (IL-10-like) using gene knockout (KO) technology. This construct (LSDV WB005KO) was then evaluated as a vaccine for sheep and goats against virulent capripoxvirus challenge. Sheep and goats were vaccinated with the construct and the animals were observed for 21days. The vaccine appeared to be safe, and did not cause disease, although it induced minor inflammation at the injection site similar to that caused by other attenuated sheep and goat pox vaccines. In addition, no virus replication was ...Continue Reading

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Mar 19, 2013·Antiviral Research·Hani BoshraShawn Babiuk

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Citations

Jan 11, 2020·Frontiers in Veterinary Science·Mahder Teffera, Shawn Babiuk
Oct 19, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ashwini Rameshrao ChapleMuthannan Andavar Ramakrishnan
May 1, 2021·Microorganisms·Jihane HamdiOuafaa Fassi Fihri
Jul 3, 2021·Frontiers in Immunology·Tesfaye Rufael ChibssaCharles Euloge Lamien
May 26, 2021·Transboundary and Emerging Diseases·Petra FayPhilippa M Beard

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