PMID: 9159146May 27, 1997Paper

A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice

Proceedings of the National Academy of Sciences of the United States of America
Britta HardyA Novogrodsky

Abstract

Monoclonal antibodies were raised against Daudi B-lymphoblastoid cell line membranes. An mAb (BAT) was selected for its ability to stimulate human and murine lymphocyte proliferation. BAT induced cytotoxicity in human and murine lymphocytes against natural killer cell-sensitive and -resistant tumor cell lines. A single intravenous administration of BAT to mice that had been inoculated with various murine tumors (e.g., B16 melanoma, 3LL carcinoma, and methylcholanthrene fibrosarcoma) resulted in striking antitumor effects as manifested by complete tumor regression and prolonged survival of the treated mice. BAT exhibited a diminished but significant antitumor effect in athymic nude mice, which are deficient in T lymphocytes, and in beige mice, which are deficient in NK cells. Furthermore, selective depletion of T or NK cells in mice reduced the response to the antitumor effect of BAT. These data indicate a dual role for T and NK cells in mediating the antitumor activity of BAT. We report here on the antitumor activity of BAT mAb on human tumor xenografts in mice. BAT demonstrated an antitumor effect in nude mice bearing human colon carcinoma (HT29) xenografts. It failed, however, to inhibit established lung metastases in severe ...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z Razi-WolfH Reiser
May 1, 1991·Cancer Metastasis Reviews·P Brodt
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Jul 1, 1994·British Journal of Haematology·I G Schmidt-WolfR S Negrin
Sep 1, 1986·Immunology Today·E A Clark, J A Ledbetter

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Citations

Jan 29, 2011·Cancer Metastasis Reviews·Roch HouotRonald Levy
Aug 1, 2000·Immunology Today·M J Glennie, P W Johnson
Jun 1, 2012·Clinical & Developmental Immunology·Ivetta DanyleskoArnon Nagler
Jul 25, 2014·Expert Opinion on Biological Therapy·Locke J Bryan, Leo I Gordon
Mar 10, 2015·Molecular Immunology·Abhisek SwaikaRichard W Joseph
Oct 11, 2012·Immunotherapy·Ivetta DanyleskoArnon Nagler
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joshua BrodyRonald Levy
Nov 4, 2000·International Immunology·A RaiterB Hardy
Jun 12, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jing LuScott A Soefje
Apr 2, 2005·International Immunology·Britta HardyAnnat Raiter
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie ElsnerRalf Dressel
Dec 5, 2008·Expert Review of Vaccines·Lina ZhaoDaiming Fan
Mar 14, 2020·Chemical Biology & Drug Design·Muhammad KalimJinbiao Zhan
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raanan BergerArnon Nagler

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