PMID: 9185714Jun 11, 1997Paper

A lymphocyte cell surface heat shock protein homologous to the endoplasmic reticulum chaperone, immunoglobulin heavy chain binding protein BIP

International Journal of Cancer. Journal International Du Cancer
C L BergerR L Edelson

Abstract

BE2 is a cell surface monomeric 78-kDa protein (BE2-78) expressed on the malignant lymphocytes of cutaneous T-cell lymphoma and adult T-cell leukemia, on some lymphocytes from patients with acquired immunodeficiency syndrome and on Epstein-Barr virus-transformed B cells. BE2-78 positivity of cutaneous T-cell lymphoma tumor cells is a useful diagnostic and prognostic determinant in evaluating patients with that disorder. The BE2-78 protein was isolated from Epstein Barr virus-transformed B cells, purified by 1- and 2-dimensional electrophoresis and then sequenced. The sequence of 4 isolated peptide fragments was highly homologous with the 78-kDa heat shock protein, BiP, an endoplasmic reticulum chaperone. The similarity between BiP and BE2-78 was supported by the demonstration that BE2-78, like BiP, avidly binds to ATP. However, polyclonal and monoclonal reagents that recognize cytoplasmic 70- and 78-kDa heat shock proteins do not detect the BE2-78 antigen on the cell surface of cutaneous T-cell lymphoma or Epstein Barr virus-transformed lymphocytes, and peptide mapping demonstrates sequence divergence, suggesting that either they are distinct or conformationally different molecules. Our results indicate that BE2-78 is a cell su...Continue Reading

References

Aug 1, 1992·Annals of Medicine·M Jäättelä, D Wissing
Sep 1, 1992·The Journal of Cell Biology·A P HuovilaS D Fuller
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F HochstenbachM B Brenner
Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·M FerrariniC Rugarli
Apr 1, 1990·The Journal of Investigative Dermatology·P W HealdR L Edelson
Aug 1, 1986·The Journal of Investigative Dermatology·C L BergerR L Edelson
Mar 1, 1995·Molecular Biology of the Cell·K PestonjamaspE J Luna
Apr 10, 1995·International Journal of Cancer. Journal International Du Cancer·G MulthoffR D Issels
May 1, 1995·Immunology Today·J Melnick, Y Argon
Oct 27, 1994·Nature·H C SchneiderW Neupert
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava
Sep 1, 1996·The Journal of Investigative Dermatology·C L BergerR L Edelson

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Citations

Aug 2, 2005·Neuro-oncology·Michael W Graner, Darell D Bigner
Apr 18, 2003·Clinical and Experimental Immunology·A W PurcellT P Gordon
Nov 10, 2015·Biotechnology and Applied Biochemistry·Hossein AghamollaeiGholamreza Farnoosh
Jan 15, 1999·Pathology Oncology Research : POR·C Soti, P Csermely
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uma Kant MisraSalvatore Vincent Pizzo
Aug 31, 2020·Journal of Cellular Physiology·Udhayakumar Gopal, Salvatore V Pizzo
Apr 10, 2020·Biotechnology and Applied Biochemistry·Hossein AghamollaeiSeyed Latif Mousavi Gargari
Jan 28, 2021·Current Tropical Medicine Reports·Berenice Morales-FrancoClaudia Lisette Charles-Niño
Mar 20, 2004·Pharmacology & Therapeutics·Amere Subbarao Sreedhar, Peter Csermely
Sep 4, 2021·Cell Stress & Chaperones·Antonio De Maio, Lawrence Hightower

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