PMID: 9450809Feb 5, 1998Paper

A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation

British Journal of Haematology
G OttH K Müller-Hermelink

Abstract

Cytogenetic investigations were performed in a case of a nodal malignant non-Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30-positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) chromosome translocation could be observed in all metaphases analysed. This finding was confirmed both by RT-PCR analysis of the NPM/ALK fusion protein and by positive staining with the p80(NPM/ALK) antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic variant of ALCL.

Citations

Apr 20, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alexandra ValeraElías Campo
Nov 15, 2000·The American Journal of Surgical Pathology·W CheukJ K Chan
Oct 19, 2005·Virchows Archiv : an International Journal of Pathology·Marcus KremerFalko Fend
Sep 1, 2005·Virchows Archiv : an International Journal of Pathology·Carsten SchraderMarkus Tiemann
Dec 19, 2008·Pathology, Research and Practice·Shih-Sung ChuangWei-Shou Hwang
Jan 13, 2009·Experimental and Molecular Pathology·Wentao HuangXiaoyan Zhou
Dec 28, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Naoko TsuyamaKengo Takeuchi
Apr 26, 2000·Pediatric Hematology and Oncology·A Kedar, R C Braylan

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