A lymphomagenic role for HIV beyond immune suppression?

Blood
Riccardo DolcettiAntonino Carbone

Abstract

Despite the immune reconstitution promoted by combined antiretroviral therapy (cART), lymphomas still represent the most common type of cancer in HIV-infected individuals. Cofactors related to immunodeficiency such as oncogenic viruses, chronic antigenic stimulation, and cytokine overproduction are thought to be the main drivers of HIV lymphomagenesis, although the current scenario does not convincingly explain the still-high incidence of lymphomas and the occurrence of peculiar lymphoma histotypes in HIV-infected patients under cART. Recent findings are challenging the current view of a mainly indirect role of HIV in lymphoma development and support the possibility that HIV may directly contribute to lymphomagenesis. In fact, mechanisms other than immune suppression involve biologic effects mediated by HIV products that are secreted and accumulate in lymphoid tissues, mainly within lymph node germinal centers. Notably, HIV-infected patients with lymphomas, but not those not affected by these tumors, were recently shown to carry HIV p17 protein variants with enhanced B-cell clonogenic activity. HIV p17 protein variants were characterized by the presence of distinct insertions at the C-terminal region of the protein responsible ...Continue Reading

References

May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Nov 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·V BlazevicK J Krohn
Jan 9, 2003·The Lancet Oncology·Antonino Carbone
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mikulas PopovicPaul Racz
Dec 29, 2007·The American Journal of Surgical Pathology·Jacqueline GoedhalsDiana Hardie
Apr 18, 2008·Current HIV/AIDS Reports·Mostafa Nokta
Jun 3, 2008·The Oncologist·Antonino CarboneGiampietro Dotti
Oct 29, 2008·Blood·Antonino CarboneThomas F Schulz
May 30, 2009·The Journal of Infectious Diseases·Alexander ZoufalyUNKNOWN ClinSurv Study Group
Jun 17, 2009·International Journal of Cancer. Journal International Du Cancer·Eleonora LeucciLorenzo Leoncini
Aug 24, 2010·Immunological Reviews·John P GrahamGail A Bishop
Apr 13, 2011·Journal of the National Cancer Institute·Meredith S ShielsEric A Engels
Oct 2, 2012·The Journal of Clinical Investigation·Ralf KüppersMartin-Leo Hansmann
Mar 5, 2013·Archives of Pathology & Laboratory Medicine·Amy ChadburnAmy A Lo
Apr 19, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meredith S ShielsLindsay M Morton
Aug 30, 2013·Retrovirology·Sabrina CurreliJoseph Bryant
Sep 4, 2013·Seminars in Cancer Biology·Annunziata GloghiniAntonino Carbone
Nov 14, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elena VendrameOtoniel Martínez-Maza
Feb 14, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chad J AchenbachUNKNOWN Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS)
Mar 13, 2014·Nature Reviews. Clinical Oncology·Antonino CarboneSilvia Franceschi
Apr 29, 2014·International Journal of Cancer. Journal International Du Cancer·Antonino CarboneEmanuela Vaccher
Jul 11, 2014·Nature Reviews. Cancer·David W Scott, Randy D Gascoyne
Sep 7, 2014·The Annals of Thoracic Surgery·Yuki MorimuraHiroshi Date
Sep 11, 2014·World Journal of Gastroenterology : WJG·Lynette LuriaLing Zhang
Feb 1, 2015·Blood·Jorge J CastilloRoberto N Miranda
Apr 2, 2015·Blood·Aaron ArveyEthel Cesarman
Apr 4, 2015·Seminars in Cancer Biology·Paolo De Paoli, Antonino Carbone
Apr 7, 2015·Seminars in Oncology·Andrew E Grulich, Claire M Vajdic
Jun 1, 2015·Seminars in Cancer Biology·Antonino Carbone, Anas Younes

❮ Previous
Next ❯

Citations

Oct 19, 2016·Medicina clínica·Rubén Fernández-ÁlvarezJosep-María Ribera
Oct 28, 2016·International Journal of Cancer. Journal International Du Cancer·Antonino CarboneRiccardo Dolcetti
Oct 19, 2016·Current Opinion in HIV and AIDS·Antonino CarboneAnnunziata Gloghini
Oct 19, 2016·Current Opinion in HIV and AIDS·Álvaro H Borges
Jan 31, 2017·Immunological Reviews·Susan Moir, Anthony S Fauci
Aug 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth L YanikEric A Engels
Nov 20, 2016·Journal of Cellular Physiology·Alberto RealeGiorgio Palù
Aug 17, 2018·Hematological Oncology·Annarita ConconiUNKNOWN Swiss HIV Cohort study (SHCS)
Jun 9, 2017·Journal of Virology·Pietro MazzucaFrancesca Caccuri
Feb 1, 2019·Journal of Cellular Physiology·Fatimata Bintou SallDiego Germini
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire Shannon-LoweAndrew I Bell
Oct 5, 2019·Journal of Clinical Medicine·Valli De ReMaurizio Mascarin
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Marinho Marques da Silva NetoÁlvaro H Borges
Dec 14, 2019·AIDS·Caroline BessonUNKNOWN Lymphovir and FHDH study groups
Nov 16, 2019·Cold Spring Harbor Perspectives in Medicine·Jordan A Baeker BispoErin K Kobetz
Apr 6, 2017·Frontiers in Immunology·Fabio E LealLishomwa C Ndhlovu
Dec 22, 2017·Journal of the National Cancer Institute·Leah ShepherdAmanda Mocroft
May 26, 2018·Cancers·Antonino Carbone, Annunziata Gloghini
Oct 13, 2017·Infectious Agents and Cancer·Francesca CaccuriStefania Marsico
Oct 31, 2019·Case Reports in Hematology·Clara BertuzziGian Gaetano Ferri
May 21, 2020·Insights Into Imaging·Edward Chege Nganga, Samuel Gitau
Jan 21, 2021·Cancers·Maria IsaguliantsJoel M Palefsky
Dec 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Francesca CaccuriArnaldo Caruso
Aug 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mariya V SivaySusan H Eshleman
Feb 3, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yann RuffieuxEliane Rohner
May 18, 2021·Frontiers in Oncology·Pedro S de CarvalhoMarcelo A Soares
Aug 11, 2021·Viruses·Yessica Sánchez-Ponce, Ezequiel M Fuentes-Pananá
Aug 10, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fabienne CabyUNKNOWN (CD4/CD8 ratio and cancer risk) project Working Group for the Collaboration of Observational HIV Epidemiological Research Eu

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Hendrik NogaiGeorg Lenz
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christophe PikettySophie Grabar
© 2022 Meta ULC. All rights reserved