A Machine Learning Approach for the Association of ki-67 Scoring with Prognostic Factors

Journal of Oncology
E Dirican, E Kiliç

Abstract

ki-67 score is a solid tumor proliferation marker being associated with the prognosis of breast carcinoma and its response to neoadjuvant chemotherapy. In the present study, we aimed to investigate the way of clustering of prognostic factors by ki-67 score using a machine learning approach and multiple correspondence analysis. In this study, 223 patients with breast carcinoma were analyzed using the random forest method for classification of prognostic factors according to ki-67 groups (<14% and >14%). Also the relationship between subgroups of prognostic factors and ki-67 scores was examined by multiple correspondence analysis. There was a clustering of molecular classification LA, 0-3 metastatic lymph node, age <50, absence of LVI, T1 tumor size with ki-67 <14% and grade III, 10 or more metastatic lymph nodes, and presence of LVI and molecular classification LB, age >50, and T3-T4 tumor size categories with ki-67 >14%. The fact that the low scores of ki-67 correlate with early stage diseases and high scores with advanced disease suggests that 14% threshold value is crucial for ki-67 score.

References

Jan 1, 1997·CA: a Cancer Journal for Clinicians·W L Donegan
Jul 31, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Natalie G CoburnBlake Cady
Dec 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A H S LeeR W Blamey
Jun 2, 2006·Breast Cancer Research : BCR·Laurel A HabelCharles P Quesenberry
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy A WoodwardYago Nieto
Jul 11, 2006·Breast Disease·Nancy Klauber-DeMore
Mar 28, 2007·World Journal of Surgery·Gaurav AgarwalPolly S Y Cheung
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José Luiz B BevilacquaKimberly J Van Zee
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca DentSteven A Narod
Jan 9, 2008·Cancer Investigation·Jeffrey PeppercornLisa A Carey
Jul 2, 2008·Breast Cancer Research and Treatment·Robin L JonesMitchell Dowsett
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent Vinh-HungChristine Bouchardy
Feb 10, 2011·The Oncologist·Nadia Harbeck, Christoph Thomssen
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jun 26, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Xavier Moles LopezChristine Decaestecker
Sep 11, 2012·Current Opinion in Oncology·Alastair M Thompson
Aug 1, 2013·Breast Cancer Research and Treatment·M J EngstrømA M Bofin
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Saroona HaroonNaveen Faridi
May 12, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Seyed-Hamid MadaniEdris Sadeghi
Feb 6, 2017·Cancer Biology & Medicine·Nahed A Soliman, Shaimaa M Yussif

❮ Previous
Next ❯

Software Mentioned

R
RandomForest
MCA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.