A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Jian GaoJianxin Chen

Abstract

Cardiac hypertrophy (CH) is an enormous risk factor in the process of heart failure development, however, there is still lack of effective treatment for CH. Mitochondrial protection is an effective way against CH. Rheum palmatum L. (rhubarb) has been used to treat chronic heart diseases such as heart failure, especially to inhibit cardiac compensatory enlargement. The aim of this study was to explore the pharmacodynamic component of rhubarb and reveal its pharmacological effects and targets in the treatment of CH. Based on network pharmacology and machine learning approach, ingredients of rhubarb and targets for CH were extracted and surflex docking was conducted for obtaining the optimal ingredient-target combination(s) and emodin-SIRT3 was identified for further functional analysis. Transverse aortic constriction or isoproterenol induced CH mice and phenylephrine injured cardiomyocytes were used to verify the mitochondria protection effect and CH improvement of emodin in vivo and in vitro by modulation of mitochondrial SIRT3 signaling. The results showed that emodin could block agonist-induced and pressure overload-mediated CH. Emodin prevented mitochondrial dysfunction and its underlying mechanism was attributed to the activ...Continue Reading

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Citations

Sep 26, 2020·Frontiers in Pharmacology·Qianqian LiYi Wang
Jan 29, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jie ChenJunwei Liu
Oct 17, 2020·Current Opinion in Cardiology·Sagar RankaAmit Noheria
Apr 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xue XuJianxin Chen
Feb 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yang ChenBin Shen
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Levi EvansBradley S Ferguson
Apr 2, 2021·Circulation Research·Kathy K GriendlingRhian M Touyz

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