PMID: 2115167Jul 1, 1990Paper

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines

Proceedings of the National Academy of Sciences of the United States of America
J M Farber

Abstract

In order to identify novel mediators synthesized in activated macrophages, a cDNA library was prepared from cultures of the mouse macrophage cell line RAW 264.7 that had been treated with lymphokine-rich conditioned medium from mitogen-stimulated mouse spleen cells. Differential plaque hybridization identified a cDNA, designated m119, that detected a 1.6-kilobase mRNA that accumulated in response to gamma-interferon (IFN-gamma) but not in response to other macrophage activators, including IFN-alpha, IFN-beta, and lipopolysaccharide. The mRNA encoded a predicted protein of Mr 14,461 containing a 21-amino acid signal peptide. The primary structure of the predicted protein indicated that it is a member of a recently described family of cytokines related to platelet factor 4, including Gro/melanoma growth stimulatory activity and neutrophil-activating peptide/interleukin 8. The selective induction of the m119 mRNA by IFN-gamma that the predicted m119 protein mediates a macrophage activity regulated by IFN-gamma. The m119 protein may be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory responses. It is proposed that the gene encoding this protein be called mig, for...Continue Reading

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Citations

Mar 31, 2010·Clinical Reviews in Allergy & Immunology·Juan Raymundo Velazquez, Luis Manuel Teran
Sep 1, 1994·Pharmacology & Therapeutics·Y Ohmori, T A Hamilton
Feb 1, 1992·Current Opinion in Immunology·S GordonS Clarke
Mar 20, 2002·Cytokine & Growth Factor Reviews·Hiroaki IkedaRobert D Schreiber
Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Dec 1, 2007·Nature Reviews. Drug Discovery·Ernest C BordenGeorge R Stark
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joyce K HuMehrdad Matloubian
Apr 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Else M BijkerRobert W Sauerwein
Feb 1, 1991·The Journal of Experimental Medicine·T M Wright, J M Farber
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Apr 17, 2001·The Journal of Experimental Medicine·W W HancockA D Luster
Oct 30, 2003·Viral Immunology·Thais P Salazar-Mather, Kirsten L Hokeness
Nov 27, 2008·Journal of Gastroenterology and Hepatology·Atsushi MatsumotoShuhji Seki
Dec 31, 2010·Journal of Virology·Timothy W PharesCornelia C Bergmann
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Feb 9, 2005·Journal of Translational Medicine·Christine V Ichim
Feb 10, 2009·Journal of Hematology & Oncology·Giuseppe CasoGerald Patejunas

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