A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging

Scientific Reports
Haruki EguchiYoshihiro Ishikawa

Abstract

Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.

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Citations

Sep 11, 2016·The Journal of Physiological Sciences : JPS·Kayoko OdaYoshihiro Ishikawa
Feb 22, 2017·Scientific Reports·Makoto OhtakeYoshihiro Ishikawa
Aug 30, 2018·Cancer Science·Taisuke AkimotoYoshihiro Ishikawa
Oct 31, 2018·Cancer Science·Masanari UmemuraYoshihiro Ishikawa
Apr 13, 2018·Oncotarget·Rina NakakajiYoshihiro Ishikawa
Apr 25, 2020·Frontiers in Chemistry·Małgorzata ŚwiętekDaniel Horák

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Methods Mentioned

BETA
dynamic light scattering
transmission
X ray
X-ray
pharmacotherapy
Assay
transmission electron microscopy

Software Mentioned

NIH Image J
WIEN2k
SHELX
CASTEP
GraphPad Prism
HKL2000
SCALEPACK
NIH J imaging
Ensemble Density Functional Theory ( EDFT
MRVision

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